Literature DB >> 3783820

Protection of chimpanzees from type B hepatitis by immunization with woodchuck hepatitis virus surface antigen.

P J Cote, M Shapiro, R E Engle, H Popper, R H Purcell, J L Gerin.   

Abstract

Two chimpanzees immunized with woodchuck hepatitis virus (WHV) surface antigen (WHsAg) developed antibodies cross-reactive with hepatitis B virus (HBV) surface antigen (HBsAg). After challenge with HBV, one animal was completely protected and the other experienced a subclinical infection, without evidence of liver disease. Three woodchucks immunized with HBsAg developed antibodies to HBsAg which did not cross-react with WHsAg. After challenge with WHV, all three woodchucks developed typical acute infections with associated hepatic lesions. Serological studies with the cross-reactive antibodies raised in chimpanzees suggested that the protective epitopes of WHsAg were related to the group a specificity of HBsAg. These studies indicated that cross-protective epitopes are shared by HBV and WHV; however, the humoral response to these epitopes can vary among species.

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Year:  1986        PMID： 3783820      PMCID： PMC253316     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

1.  A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

Authors:  J Summers; J M Smolec; R Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

Review 2.  Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

Authors:  W Szmuness
Journal:  Prog Med Virol       Date:  1978

3.  Serological relationship of woodchuck hepatitis virus to human hepatitis B virus.

Authors:  B G Werner; J M Smolec; R Snyder; J Summers
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

4.  Three recently described animal virus models for human hepatitis B virus.

Authors:  J Summers
Journal:  Hepatology       Date:  1981 Mar-Apr       Impact factor: 17.425

5.  Biophysical characterization of the adr subtype of hepatitis B antigen and preparation of anti-r sera in rabbits.

Authors:  J L Gerin; R M Faust; P V Holland
Journal:  J Immunol       Date:  1975-07       Impact factor: 5.422

6.  Antigenic and structural relationships of the surface antigens of hepatitis B virus, ground squirrel hepatitis virus, and woodchuck hepatitis virus.

Authors:  M A Feitelson; P L Marion; W S Robinson
Journal:  J Virol       Date:  1981-08       Impact factor: 5.103

Review 7.  Genetic variation among hepatitis B and related viruses.

Authors:  W S Robinson
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

8.  Anti-idiotypic antibody vaccine for type B viral hepatitis in chimpanzees.

Authors:  R C Kennedy; J W Eichberg; R E Lanford; G R Dreesman
Journal:  Science       Date:  1986-04-11       Impact factor: 47.728

Review 9.  Type B hepatitis: a review of current prospects for a safe and effective vaccine.

Authors:  V J McAuliffe; R H Purcell; J L Gerin
Journal:  Rev Infect Dis       Date:  1980 May-Jun

10.  Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States.

Authors:  W Szmuness; C E Stevens; E J Harley; E A Zang; W R Oleszko; D C William; R Sadovsky; J M Morrison; A Kellner
Journal:  N Engl J Med       Date:  1980-10-09       Impact factor: 91.245
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  8 in total

Review 1.  The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection.

Authors:  Stephan Menne; Paul J Cote
Journal:  World J Gastroenterol       Date:  2007-01-07       Impact factor: 5.742

2.  Deficiencies in the acute-phase cell-mediated immune response to viral antigens are associated with development of chronic woodchuck hepatitis virus infection following neonatal inoculation.

Authors:  Stephan Menne; Carol A Roneker; Michael Roggendorf; John L Gerin; Paul J Cote; Bud C Tennant
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

3.  Natural history of experimental woodchuck hepatitis virus infection: molecular virologic features of the pancreas, kidney, ovary, and testis.

Authors:  B E Korba; T L Brown; F V Wells; B Baldwin; P J Cote; H Steinberg; B C Tennant; J L Gerin
Journal:  J Virol       Date:  1990-09       Impact factor: 5.103

4.  Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host.

Authors:  C Seeger; B Baldwin; W E Hornbuckle; A E Yeager; B C Tennant; P Cote; L Ferrell; D Ganem; H E Varmus
Journal:  J Virol       Date:  1991-04       Impact factor: 5.103

5.  DNA prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model.

Authors:  Anna D Kosinska; Lena Johrden; Ejuan Zhang; Melanie Fiedler; Anja Mayer; Oliver Wildner; Mengji Lu; Michael Roggendorf
Journal:  J Virol       Date:  2012-06-20       Impact factor: 5.103

6.  Protection against woodchuck hepatitis virus (WHV) infection by gene gun coimmunization with WHV core and interleukin-12.

Authors:  R García-Navarro; B Blanco-Urgoiti; P Berraondo; R Sánchez de la Rosa; A Vales; S Hervás-Stubbs; J J Lasarte; F Borrás; J Ruiz; J Prieto
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

7.  Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune responses in mice and woodchucks.

Authors:  Mengji Lu; Masanori Isogawa; Yang Xu; Gero Hilken
Journal:  J Virol       Date:  2005-05       Impact factor: 5.103

8.  Immunization of woodchucks with plasmids expressing woodchuck hepatitis virus (WHV) core antigen and surface antigen suppresses WHV infection.

Authors:  M Lu; G Hilken; J Kruppenbacher; T Kemper; R Schirmbeck; J Reimann; M Roggendorf
Journal:  J Virol       Date:  1999-01       Impact factor: 5.103
  8 in total

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