Literature DB >> 3781919

Triacsins, new inhibitors of acyl-CoA synthetase produced by Streptomyces sp.

S Omura, H Tomoda, Q M Xu, Y Takahashi, Y Iwai.   

Abstract

Triacsins A and B, new inhibitors of acyl-CoA synthetase, were isolated from the cultured broth of Streptomyces sp. strain SK-1894. The structurally related compounds WS-1228 A and B, known as hypotensive vasodilators, were also found to inhibit acyl-CoA synthetase. The four compounds have in common a N-hydroxytriazene moiety in their structures. The IC50 values for triacsin A and WS-1228 A were 5.5 and 3.6 micrograms/ml, respectively.

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Year:  1986        PMID： 3781919     DOI： 10.7164/antibiotics.39.1211

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  23 in total

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