Literature DB >> 3780978

Type II Ca2+/calmodulin-dependent protein kinase binds to actin filaments in a calmodulin-sensitive manner.

Y Ohta, E Nishida, H Sakai.   

Abstract

Multifunctional type II Ca2+/calmodulin-dependent protein kinase purified from rat brain cytosol was found to bind to actin filaments in vitro. The binding was saturable, and the dissociation constant for the binding was determined to be about 4 X 10(-8)M. Electron microscopic observation indicated that the kinase binds to the side of actin filaments. Calmodulin inhibited the binding of the kinase to actin filaments in a Ca2+-dependent manner. The Ca2+/calmodulin-regulated binding of the kinase to actin filaments revealed here may be important for the substrate recognition of the kinase.

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Year:  1986        PMID： 3780978     DOI： 10.1016/0014-5793(86)81061-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  20 in total

1.  Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations.

Authors:  K Ulrich Bayer; Paul De Koninck; Howard Schulman
Journal:  EMBO J       Date:  2002-07-15       Impact factor: 11.598

Review 2.  Calmodulin-dependent protein kinase II. Multifunctional roles in neuronal differentiation and synaptic plasticity.

Authors:  P T Kelly
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

3.  CaMKIIbeta association with the actin cytoskeleton is regulated by alternative splicing.

Authors:  Heather O'Leary; Erika Lasda; K Ulrich Bayer
Journal:  Mol Biol Cell       Date:  2006-08-23       Impact factor: 4.138

4.  Structure and composition of the postsynaptic density during development.

Authors:  Matthew T Swulius; Yoshihisa Kubota; Amélie Forest; M Neal Waxham
Journal:  J Comp Neurol       Date:  2010-10-15       Impact factor: 3.215

5.  Overexpression of Ca2+/calmodulin-dependent protein kinase II in PC12 cells alters cell growth, morphology, and nerve growth factor-induced differentiation.

Authors:  T Massé; P T Kelly
Journal:  J Neurosci       Date:  1997-02-01       Impact factor: 6.167

6.  Quantitative estimates of the cytoplasmic, PSD, and NMDAR-bound pools of CaMKII in dendritic spines.

Authors:  Bihua Feng; Sridhar Raghavachari; John Lisman
Journal:  Brain Res       Date:  2011-08-27       Impact factor: 3.252

7.  An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle.

Authors:  K U Bayer; J Löhler; K Harbers
Journal:  Mol Cell Biol       Date:  1996-01       Impact factor: 4.272

Review 8.  Targeting of calcium/calmodulin-dependent protein kinase II.

Authors:  Roger J Colbran
Journal:  Biochem J       Date:  2004-02-15       Impact factor: 3.857

9.  Calcium-calmodulin-dependent protein kinase II isoforms differentially impact the dynamics and structure of the actin cytoskeleton.

Authors:  Laurel Hoffman; Madeline M Farley; M Neal Waxham
Journal:  Biochemistry       Date:  2013-02-04       Impact factor: 3.162

10.  Localization of calmodulin positive immunoreactivity in the surface epidermis of the brown trout, Salmo trutta.

Authors:  G Zaccone; S Fasulo; L Ainis; A Contini
Journal:  Histochemistry       Date:  1989
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