Literature DB >> 3780820

2-Mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria.

J Mårtensson, T Denneberg, B Kågedal.   

Abstract

A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50-300 mumol/24h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the metabolite could be a potential hazard in oxidation of fatty acids.

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Year:  1986        PMID： 3780820     DOI： 10.1007/bf00871000

Source DB:  PubMed          Journal:  Eur J Clin Pharmacol        ISSN： 0031-6970            Impact factor:   2.953


  6 in total

1.  Inhibition in vitro of acyl-CoA dehydrogenases by 2-mercaptoacetate in rat liver mitochondria.

Authors:  F Bauché; D Sabourault; Y Giudicelli; J Nordmann; R Nordmann
Journal:  Biochem J       Date:  1983-12-01       Impact factor: 3.857

2.  Determination of non-protein-bound N-acetylcysteine in plasma by high-performance liquid chromatography.

Authors:  B Kågedal; M Källberg; J Mårtensson
Journal:  J Chromatogr       Date:  1984-11-09

3.  Determination of 2-mercaptopropionylglycine in plasma and urine by high-performance liquid chromatography.

Authors:  B Kågedal; M Carlsson; T Denneberg
Journal:  J Chromatogr       Date:  1986-08-02

4.  Determination of 3-mercaptolactate, mercaptoacetate and N-acetylcysteine in urine by gas chromatography.

Authors:  U Hannestad; B Sörbo
Journal:  Clin Chim Acta       Date:  1979-07-16       Impact factor: 3.786

5.  3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria.

Authors:  E Sabbagh; D Cuebas; H Schulz
Journal:  J Biol Chem       Date:  1985-06-25       Impact factor: 5.157

6.  Alternative treatment of cystinuria with alpha-merkaptopropionylglycine, Thiola.

Authors:  T Denneberg; J O Jeppsson; P Stenberg
Journal:  Proc Eur Dial Transplant Assoc       Date:  1983
  6 in total
  1 in total

1.  The pharmacokinetics of tiopronin and its principal metabolite (2-mercaptopropionic acid) after oral administration to healthy volunteers.

Authors:  B Hercelin; P Leroy; A Nicolas; C Gavriloff; D Chassard; J J Thébault; M T Reveillaud; M F Salles; P Netter
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953
  1 in total

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