Literature DB >> 3779893

In vitro assays for detecting carcinogenic mineral fibres: a comparison of two assays and the role of fibre size.

G M Brown, H Cowie, J M Davis, K Donaldson.   

Abstract

The activities of 13 carcinogenic fibrous dust samples were compared in two in vitro test systems using V79/4 and A549 cells. Eleven of the dusts had similar ranks in both assays but two samples had disparate results. The relationship between the fibre length and diameter distributions of 12 of the samples and their activity in each assay was examined. A significant association between fibre length and biological activity occurred in both assays. This relationship showed increasing strength of association with increasing fibre length. The only significant association between fibre diameter and activity in vitro was demonstrated with fibres greater than 0.2 micron in the A549 assay.

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Year:  1986        PMID： 3779893     DOI： 10.1093/carcin/7.12.1971

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  8 in total

1.  Inflammation generating potential of long and short fibre amosite asbestos samples.

Authors:  K Donaldson; G M Brown; D M Brown; R E Bolton; J M Davis
Journal:  Br J Ind Med       Date:  1989-04

2.  Chemical differences between long and short amosite asbestos: differences in oxidation state and coordination sites of iron, detected by infrared spectroscopy.

Authors:  A Graham; J Higinbotham; D Allan; K Donaldson; P H Beswick
Journal:  Occup Environ Med       Date:  1999-09       Impact factor: 4.402

3.  A commentary on Roggli's "The So-Called Short-Fiber Controversy".

Authors:  David Egilman; Triet Tran
Journal:  Int J Occup Environ Health       Date:  2016-05-24

4.  Asbestos fibre length-dependent detachment injury to alveolar epithelial cells in vitro: role of a fibronectin-binding receptor.

Authors:  K Donaldson; B G Miller; E Sara; J Slight; R C Brown
Journal:  Int J Exp Pathol       Date:  1993-06       Impact factor: 1.925

Review 5.  Use of mesothelial cell cultures to assess the carcinogenic potency of mineral or man made fibers.

Authors:  A Renier; M Yegles; A Buard; H Dong; L Kheuang; L Saint-Etienne; P Laurent; M C Jaurand
Journal:  Cell Biol Toxicol       Date:  1992 Jul-Sep       Impact factor: 6.691

Review 6.  Quantification of short and long asbestos fibers to assess asbestos exposure: a review of fiber size toxicity.

Authors:  Guillaume Boulanger; Pascal Andujar; Jean-Claude Pairon; Marie-Annick Billon-Galland; Chantal Dion; Pascal Dumortier; Patrick Brochard; Annie Sobaszek; Pierre Bartsch; Christophe Paris; Marie-Claude Jaurand
Journal:  Environ Health       Date:  2014-07-21       Impact factor: 5.984

Review 7.  Review of animal/in vitro data on biological effects of man-made fibers.

Authors:  S A Ellouk; M C Jaurand
Journal:  Environ Health Perspect       Date:  1994-06       Impact factor: 9.031

Review 8.  Minerals, fibrosis, and the lung.

Authors:  A G Heppleston
Journal:  Environ Health Perspect       Date:  1991-08       Impact factor: 9.031
  8 in total

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