Literature DB >> 3779193

Deferoxamine increases skin flap survival: additional evidence of free radical involvement in ischaemic flap surgery.

M F Angel, K Narayanan, W M Swartz, S S Ramasastry, D B Kuhns, R E Basford, J W Futrell.   

Abstract

This study presents further evidence of free radical involvement in skin flap necrosis in a dorsal rat flap model. Rats receiving deferoxamine, a free radical scavenger and iron chelator had significantly less necrosis (p less than 0.001) than saline treated rats. In a separate experiment, tissue determinations for malonyldialdehyde (MDA) were consistent with the survival results in showing a significant decrease in MDA in all biopsy sites (p less than 0.05 or less), indicative of reduced lipoperoxidation in the deferoxamine treated rats.

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Year:  1986        PMID： 3779193     DOI： 10.1016/0007-1226(86)90115-3

Source DB:  PubMed          Journal:  Br J Plast Surg        ISSN： 0007-1226


  4 in total

1.  Pathology of warm ischaemia and reperfusion injury in adipomusculocutaneous flaps.

Authors:  H Nishikawa; S Manek; S S Barnett; A Charlett; C J Green
Journal:  Int J Exp Pathol       Date:  1993-02       Impact factor: 1.925

2.  Clinically achievable plasma deferoxamine concentrations are therapeutic in a rat model of Pneumocystis carinii pneumonia.

Authors:  S Merali; K Chin; L Del Angel; R W Grady; M Armstrong; A B Clarkson
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

3.  Local injection of deferoxamine improves neovascularization in ischemic diabetic random flap by increasing HIF-1α and VEGF expression.

Authors:  Chen Wang; Yuanyuan Cai; Yun Zhang; Zhuyou Xiong; Guangzao Li; Lei Cui
Journal:  PLoS One       Date:  2014-06-25       Impact factor: 3.240

Review 4.  Nutritional and Pharmacological Effects on Oxidative Stress in Soft Tissue and Bone Remodeling.

Authors:  Benjamin M Savasky; David P Mascotti; Naren Patel; Edgardo Rodriguez-Collazo
Journal:  J Nutr Metab       Date:  2018-12-27
  4 in total

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