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Literature DB >> 3778861

Retinal cotton-wool spots: an early finding in diabetic retinopathy?

M S Roy, M E Rick, K E Higgins, J C McCulloch.

Abstract

Five insulin dependent diabetic patients are reported on who had a few small retinal cotton-wool spots or 'soft exudates' either totally isolated or associated with fewer than 10 microaneurysms. These observations suggest that cotton-wool spots may be an early finding in diabetic retinopathy. Significant biological abnormalities in these patients were high levels of glycosylated haemoglobin and mild increases in thrombin generation, indicating slight activation of the coagulation system. The possible significance of these clinical and biological findings is discussed.

Entities: Disease Gene Species

Mesh：

Substances：
Glycated Hemoglobin A

Year: 1986 PMID： 3778861 PMCID： PMC1040826 DOI： 10.1136/bjo.70.10.772

Source DB: PubMed Journal: Br J Ophthalmol ISSN： 0007-1161 Impact factor: 4.638

37 in total

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Journal: Lancet Date: 1959-10-24 Impact factor: 79.321

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Journal: Diabetes Date: 1976 Impact factor: 9.461

Review 3. The sorbitol pathway and the complications of diabetes.

Authors: K H Gabbay
Journal: N Engl J Med Date: 1973-04-19 Impact factor: 91.245

4. Intravascular coagulation in acute leukemia: clinical and subclinical abnormalities.

Authors: H R Gralnick; S Marchesi; H Givelber
Journal: Blood Date: 1972-11 Impact factor: 22.113

5. Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure.

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Journal: Blood Date: 1977-01 Impact factor: 22.113

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Authors: D Toussaint
Journal: J Fr Ophtalmol Date: 1982 Impact factor: 0.818

7. Effect of multimeric structure of the factor VIII/von Willebrand factor protein on binding to platelets.

Authors: H R Gralnick; S B Williams; D K Morisato
Journal: Blood Date: 1981-08 Impact factor: 22.113

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Authors: J F Mustand; M A Packham
Journal: N Engl J Med Date: 1984-09-06 Impact factor: 91.245

9. The use of vitreous fluorophotometry to distinguish between diabetics with and without observable retinopathy: effect of vitreous abnormalities on the measurement.

Authors: T C Prager; H H Chu; C A Garcia; R E Anderson; J B Field; E A Orzeck; J P Comstock
Journal: Invest Ophthalmol Vis Sci Date: 1983-01 Impact factor: 4.799

Retinal cotton-wool spots: an early finding in diabetic retinopathy?

1. Diabetic retinopathy: a new approach.

2. The problems of retinal blood flow in diabetes.

Review 3. The sorbitol pathway and the complications of diabetes.

4. Intravascular coagulation in acute leukemia: clinical and subclinical abnormalities.

5. Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure.

6. [Fluoroangiography of the retina in diabetes].

7. Effect of multimeric structure of the factor VIII/von Willebrand factor protein on binding to platelets.

8. Platelets and diabetes mellitus.

9. The use of vitreous fluorophotometry to distinguish between diabetics with and without observable retinopathy: effect of vitreous abnormalities on the measurement.

10. Vitreous fluorophotometry in patients with no or minimal diabetic retinopathy.

1. Cotton-wool spots and retinal light sensitivity in diabetic retinopathy.

2. Loss of heparan sulphate proteoglycan and retinal microinfarcts in diabetes mellitus.

3. First microangiographic abnormalities in childhood diabetes--types of lesions.

4. Short wavelength automated perimetry can detect visual field changes in diabetic patients without retinopathy.