Literature DB >> 3778807

Role of aminoglutethimide in male breast cancer.

A L Harris, M Dowsett, R Stuart-Harris, I E Smith.   

Abstract

Five men with advanced breast cancer were treated with aminoglutethimide (AG) plus replacement dose hydrocortisone. None of the 4 patients with intact testes responded, although 3 did so subsequently to tamoxifen. The previously orchidectomized patient responded to aminoglutethimide for 14 months. Oestrone and oestradiol were suppressed by AG in all patients, but not to the levels achieved by orchidectomy. AG produced substantial further oestrogen suppression in the orchidectomized patient and should only be used after orchidectomy.

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Year:  1986        PMID： 3778807      PMCID： PMC2001494          DOI： 10.1038/bjc.1986.223

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  17 in total

Review 1.  Male breast cancer: a review.

Authors:  F L Meyskens; D C Tormey; J P Neifeld
Journal:  Cancer Treat Rev       Date:  1976-06       Impact factor: 12.111

2.  Estrogen synthesis in normal and hypogonadal men. Quantitative studies on the precursor role of testosterone.

Authors:  B J Epstein; M C Raheja; E Frow; W I Morse
Journal:  Can J Biochem       Date:  1966-06

3.  Treatment of advanced male breast cancer.

Authors:  W G Kraybill; R Kaufman; D Kinne
Journal:  Cancer       Date:  1981-05-01       Impact factor: 6.860

4.  Aminoglutethimide in the treatment of advanced postmenopausal breast cancer.

Authors:  A L Harris; T J Powles; I E Smith
Journal:  Cancer Res       Date:  1982-08       Impact factor: 12.701

5.  Clinical correlations of steroid receptors and male breast cancer.

Authors:  R B Everson; M E Lippman; E B Thompson; W L McGuire; J L Wittliff; E R De Sombre; E V Jensen; A Singhakowinta; S C Brooks; J P Neifeld
Journal:  Cancer Res       Date:  1980-04       Impact factor: 12.701

6.  Use of tamoxifen in advanced male breast cancer.

Authors:  J S Patterson; L A Battersby; B K Bach
Journal:  Cancer Treat Rep       Date:  1980 Jun-Jul

7.  Human testis does not secrete oestrone sulphate.

Authors:  F C Wu; I A Swanston; T B Hargreave; D T Baird
Journal:  J Endocrinol       Date:  1982-02       Impact factor: 4.286

8.  Acute effects of aminoglutethimide on testicular steroidogenesis in normal men.

Authors:  R J Santen; N Cohn; R Misbin; E Samojlik; E Foltz
Journal:  J Clin Endocrinol Metab       Date:  1979-10       Impact factor: 5.958

9.  Endocrine and therapeutic effects of aminoglutethimide in premenopausal patients with breast cancer.

Authors:  A L Harris; M Dowsett; S L Jeffcoate; J A McKinna; M Morgan; I E Smith
Journal:  J Clin Endocrinol Metab       Date:  1982-10       Impact factor: 5.958

10.  The results of diethylstilboestrol therapy for recurrent and metastatic carcinoma of the male breast.

Authors:  G G Ribeiro
Journal:  Br J Cancer       Date:  1976-04       Impact factor: 7.640
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  4 in total

Review 1.  Mechanisms of action of aminoglutethimide as endocrine therapy of breast cancer.

Authors:  P E Lønning; S Kvinnsland
Journal:  Drugs       Date:  1988-06       Impact factor: 9.546

Review 2.  Male breast cancer.

Authors:  Matthew D Volm
Journal:  Curr Treat Options Oncol       Date:  2003-04

Review 3.  Male breast carcinoma: radiotherapy contributed to favorable local control in two cases and related literature review.

Authors:  Min Liu; Qiang Wang; Bin Liu; Ling Gao; Di Wu; Shuo Yang; Bailong Liu; Lihua Dong
Journal:  Eur J Med Res       Date:  2015-11-26       Impact factor: 2.175

Review 4.  Management of Male Breast Cancer: The Journey so Far and Future Directions.

Authors:  Quratulain Anna Sabih; Jessica Young; Kazuaki Takabe
Journal:  World J Oncol       Date:  2021-12-08
  4 in total

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