Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The cochlea of the spontaneously diabetic mouse. I. Electron microscopic observation of KK mice.

Literature DB >> 3778298

The cochlea of the spontaneously diabetic mouse. I. Electron microscopic observation of KK mice.

Abstract

We examined the cochleae of the spontaneously diabetic KK mice by using transmission electron microscopy. At the age of 3 months, the mice started to show evidence for glycosuria and hyperglycemia, and tissue sections showed beginning cochlear pathology. The pathological changes present were found to be limited to the stria vascularis: protrusions of marginal cells, swellings of intermediate cells and widening of intercellular spaces were the main findings seen. These changes progressed with age, but were not observed in age-matched non-diabetic 57BL/6 mice. The possible mechanism of diabetes causing cochlear pathology is discussed.

Entities: Disease Species

Mesh：

Year: 1986 PMID： 3778298 DOI： 10.1007/bf00464437

Source DB: PubMed Journal: Arch Otorhinolaryngol ISSN： 0302-9530

10 in total

1. Hearing in diabetics.

Authors: A Axelsson; K Sigroth; D Vertes
Journal: Acta Otolaryngol Suppl Date: 1978

2. The inner ear in experimental diabetes mellitus.

Authors: G Marshak
Journal: Acta Otolaryngol Suppl Date: 1972

Review 3. Mechanisms initiating cataract formation. Proctor Lecture.

Authors: J H Kinoshita
Journal: Invest Ophthalmol Date: 1974-10

4. The inner ear in diabetes mellitus.

Authors: M Kovar
Journal: ORL J Otorhinolaryngol Relat Spec Date: 1973 Impact factor: 1.538

5. Dysfunctions of energy releasing and consuming processes of the cochlea.

Authors: R Thalmann; J Kusakari; T Miyoshi
Journal: Laryngoscope Date: 1973-10 Impact factor: 3.325

6. Pathological changes of the inner ear and central auditory pathway in diabetics.

Authors: K Makishima; K Tanaka
Journal: Ann Otol Rhinol Laryngol Date: 1971-04 Impact factor: 1.547

7. Effects of chemical alteration in the endolymph on the cochlear potentials.

Authors: T Konishi; E Kelsey; G T Singleton
Journal: Acta Otolaryngol Date: 1966 Oct-Nov Impact factor: 1.494

8. Inner ear pathology in experimental diabetes.

Authors: O A Costa
Journal: Laryngoscope Date: 1967-01 Impact factor: 3.325

9. Experimental diabetes and the inner ear. A proposed biologic model.

Authors: J H Gladney
Journal: Ann Otol Rhinol Laryngol Date: 1978 Jan-Feb Impact factor: 1.547

10. Cochlear fluid balance. A clinical/research overview.

Authors: A J Duvall; P A Santi; M J Hukee
Journal: Ann Otol Rhinol Laryngol Date: 1980 Jul-Aug Impact factor: 1.547