Literature DB >> 3777909

Antifungal macrodiolide from Streptomyces sp.

H R Jois, A Sarkar, S Gurusiddaiah.   

Abstract

Aerobic fermentation cultures of Streptomyces sp. produced an antifungal macrodiolide. This new antibiotic consists of two units of homononactic acid linked to form a cyclic diester. An unknown polypeptide was also isolated in trace quantities. The antibiotic with polypeptide complex showed high levels of antifungal activity compared with that of the macrodiolide alone. The macrodiolide also showed a stimulatory effect on some species of fungi. The production, purification, and characterization of these compounds are reported.

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Year:  1986        PMID： 3777909      PMCID： PMC180580          DOI： 10.1128/AAC.30.3.458

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Conformation of tetranactin in solution.

Authors:  Y Kyogoku; M Ueno; H Akutsu; Y Nawata
Journal:  Biopolymers       Date:  1975-05       Impact factor: 2.505

2.  Pantomycin: a new antimicrobial antibiotic.

Authors:  S Gurusiddaiah; L D Winward; D Burger; S O Graham
Journal:  Mycologia       Date:  1979 Jan-Feb       Impact factor: 2.696

3.  An additional source of macrotetrolide antibiotics.

Authors:  L L Smith
Journal:  J Antibiot (Tokyo)       Date:  1975-12       Impact factor: 2.649

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Authors:  H Gerlach; R Hütter; W Keller-Schierlein; J Seibl; H Zähner
Journal:  Helv Chim Acta       Date:  1967-09       Impact factor: 2.164

5.  Fourier transform C-13 NMR analysis of some free and potassium-ion complexed antibiotics.

Authors:  M Ohnishi; M C Fedarko; J D Baldeschwieler
Journal:  Biochem Biophys Res Commun       Date:  1972-01-14       Impact factor: 3.575

6.  Treponemycin, a nitrile antibiotic active against Treponema hyodysenteriae.

Authors:  S K Singh; S Gurusiddaiah; J W Whalen
Journal:  Antimicrob Agents Chemother       Date:  1985-02       Impact factor: 5.191

7.  Production, purification, and characterization of chandramycin, a polypeptide antibiotic from Streptomyces lydicus.

Authors:  S K Singh; S Gurusiddaiah
Journal:  Antimicrob Agents Chemother       Date:  1984-09       Impact factor: 5.191

8.  Tetranactin, a new miticidal antibiotic. I. Isolation, characterization and properties of tetranactin.

Authors:  K Ando; H Oishi; S Hirano; T Okutomi; K Suzuki
Journal:  J Antibiot (Tokyo)       Date:  1971-06       Impact factor: 2.649

9.  Tetranactin, a new miticidal antibiotic. II. Structure of tetranactin.

Authors:  K Ando; Y Murakami; Y Nawata
Journal:  J Antibiot (Tokyo)       Date:  1971-07       Impact factor: 2.649

10.  [ 13 C nuclear magnetic resonance spectra of the reciprocal of macrotetrolide antibiotics with Na + , K + , Rb Rb + , Cs + , NH 4+ and Ba 2+ ].

Authors:  E Pretsch; M Vasák; W Simon
Journal:  Helv Chim Acta       Date:  1972       Impact factor: 2.164
  10 in total
  2 in total

1.  Antimicrobial activities of Streptomyces pulcher, S. canescens and S. citreofluorescens against fungal and bacterial pathogens of tomato in vitro.

Authors:  M S el-Abyad; M A el-Sayed; A R el-Shanshoury; S M el-Sabbagh
Journal:  Folia Microbiol (Praha)       Date:  1996       Impact factor: 2.099

2.  Genetic localization and molecular characterization of the nonS gene required for macrotetrolide biosynthesis in Streptomyces griseus DSM40695.

Authors:  W C Smith; L Xiang; B Shen
Journal:  Antimicrob Agents Chemother       Date:  2000-07       Impact factor: 5.191
  2 in total

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