Literature DB >> 3774840

Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.

B Vilain, V Lagente, C Touvay, S Desquand, J Randon, J Lefort, P Braquet, B B Vargaftig.   

Abstract

BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists.

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Year:  1986        PMID： 3774840     DOI： 10.1016/0031-6989(86)90044-5

Source DB:  PubMed          Journal:  Pharmacol Res Commun        ISSN： 0031-6989


  5 in total

1.  Occurrence of disseminated intravascular coagulation (DIC) in active systemic anaphylaxis: role of platelet-activating factor.

Authors:  I H Choi; T Y Ha; D G Lee; J S Park; J H Lee; Y M Park; H K Lee
Journal:  Clin Exp Immunol       Date:  1995-06       Impact factor: 4.330

2.  Interference of BN 52021, an antagonist of PAF, with different forms of active anaphylaxis in the guinea-pig: importance of the booster injection.

Authors:  S Desquand; J Lefort; C Dumarey; B B Vargaftig
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739

3.  Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages.

Authors:  A G Stewart; G J Dusting
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739

4.  Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice.

Authors:  I H Choi; Y M Shin; J S Park; M S Lee; E H Han; O H Chai; S Y Im; T Y Ha; H K Lee
Journal:  J Exp Med       Date:  1998-11-02       Impact factor: 14.307

5.  Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction.

Authors:  Il-Whan Choi; Young-Suk Kim; Dae-Ki Kim; Jung-Hwa Choi; Kook-Heon Seo; Shun-Young Im; Keun-Sang Kwon; Myung-Shik Lee; Tai-You Ha; Hern-Ku Lee
Journal:  J Exp Med       Date:  2003-06-30       Impact factor: 14.307
  5 in total

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