Literature DB >> 377484

An extrinsic membrane polypeptide associated with high-molecular-weight protein aggregates in human cataract.

A Spector, M H Garner, W H Garner, D Roy, P Farnsworth, S Shyne.   

Abstract

A 43,000-dalton polypeptide has been isolated from the high-molecular-weight disulfide-rich fraction of the water-insoluble protein of human cataractous lenses. On the basis of immunochemical reactivity and fluorescent antibody binding, this polypeptide is localized in the membrane region of the lens cell. This observation suggests an interaction between the soluble lens proteins and membrane-associated polypeptides in the formation of large protein aggregates which may cause cataract.

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Year:  1979        PMID： 377484     DOI： 10.1126/science.377484

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  AlphaB-crystallin: a Golgi-associated membrane protein in the developing ocular lens.

Authors:  Rajendra K Gangalum; Suraj P Bhat
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-02-14       Impact factor: 4.799

2.  Suppression of phase separation in solutions of bovine gamma IV-crystallin by polar modification of the sulfur-containing amino acids.

Authors:  J Pande; C Berland; M Broide; O Ogun; J Melhuish; G Benedek
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

3.  Nondisulfide polymerization of gamma- and beta-crystallins in the human lens.

Authors:  D Roy; J Dillon; E Wada; W Chaney; A Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1984-05       Impact factor: 11.205

4.  Selective oxidation of cysteine and methionine in normal and senile cataractous lenses.

Authors:  M H Garner; A Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

5.  Biochemical evidence for membrane disintegration in human cataracts.

Authors:  M H Garner; D Roy; L Rosenfeld; W H Garner; A Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1981-03       Impact factor: 11.205

6.  Identification of a 70,000-D protein in lens membrane junctional domains.

Authors:  J Kistler; B Kirkland; S Bullivant
Journal:  J Cell Biol       Date:  1985-07       Impact factor: 10.539

7.  Nonenzymatic glycosylation, sulfhydryl oxidation, and aggregation of lens proteins in experimental sugar cataracts.

Authors:  V M Monnier; V J Stevens; A Cerami
Journal:  J Exp Med       Date:  1979-11-01       Impact factor: 14.307
  7 in total

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