Literature DB >> 3774226

Calcium-dependent spike after-current induces burst firing in magnocellular neurosecretory cells.

C W Bourque.   

Abstract

Magnocellular neurosecretory cells (MNCs) were impaled in perfused explants of rat hypothalamus. Application of a voltage clamp after 1-5 current-evoked spikes revealed a tetrodotoxin-resistant, but Cd2+-sensitive inward current. From a threshold near -85 mV, the amplitude of this current increased as post-spike commands were made to more positive potentials. Following its activation, the current-voltage relation of the cell displayed a region of negative resistance which crossed the spike threshold. This Ca2+-dependent spike after-current can therefore induce and sustain burst firing in MNCs.

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Year:  1986        PMID： 3774226     DOI： 10.1016/0304-3940(86)90464-7

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  38 in total

1.  Excitatory role of the hyperpolarization-activated inward current in phasic and tonic firing of rat supraoptic neurons.

Authors:  M Ghamari-Langroudi; C W Bourque
Journal:  J Neurosci       Date:  2000-07-01       Impact factor: 6.167

2.  Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus.

Authors:  Glenn I Hatton; Qin Zhao Yang
Journal:  J Neurosci       Date:  2002-01-01       Impact factor: 6.167

3.  Autocrine feedback inhibition of plateau potentials terminates phasic bursts in magnocellular neurosecretory cells of the rat supraoptic nucleus.

Authors:  Colin H Brown; Charles W Bourque
Journal:  J Physiol       Date:  2004-04-23       Impact factor: 5.182

4.  AHP's, HAP's and DAP's: how potassium currents regulate the excitability of rat supraoptic neurones.

Authors:  Peter Roper; Joseph Callaway; Talent Shevchenko; Ryoichi Teruyama; William Armstrong
Journal:  J Comput Neurosci       Date:  2003 Nov-Dec       Impact factor: 1.621

5.  Ionic basis for the intrinsic activation of rat supraoptic neurones by hyperosmotic stimuli.

Authors:  C W Bourque
Journal:  J Physiol       Date:  1989-10       Impact factor: 5.182

6.  Voltage-gated calcium currents in the magnocellular neurosecretory cells of the rat supraoptic nucleus.

Authors:  T E Fisher; C W Bourque
Journal:  J Physiol       Date:  1995-08-01       Impact factor: 5.182

7.  Electrophysiological characteristics of immunochemically identified rat oxytocin and vasopressin neurones in vitro.

Authors:  W E Armstrong; B N Smith; M Tian
Journal:  J Physiol       Date:  1994-02-15       Impact factor: 5.182

8.  Regulation of spontaneous phasic firing of rat supraoptic vasopressin neurones in vivo by glutamate receptors.

Authors:  R Nissen; B Hu; L P Renaud
Journal:  J Physiol       Date:  1995-04-15       Impact factor: 5.182

9.  Caesium blocks depolarizing after-potentials and phasic firing in rat supraoptic neurones.

Authors:  M Ghamari-Langroudi; C W Bourque
Journal:  J Physiol       Date:  1998-07-01       Impact factor: 5.182

10.  Distinct omega-agatoxin-sensitive calcium currents in somata and axon terminals of rat supraoptic neurones.

Authors:  T E Fisher; C W Bourque
Journal:  J Physiol       Date:  1995-12-01       Impact factor: 5.182
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