| Literature DB >> 3773052 |
E J Stott, L A Ball, K K Young, J Furze, G W Wertz.
Abstract
Recombinant vaccinia virus vectors were constructed which expressed the major surface glycoprotein G of human respiratory syncytial (RS) virus. The biological activity of the G protein expressed from these vectors was assayed. Inoculation of rabbits with live recombinant virus induced high titers of antibody which specifically immunoprecipitated RS virus G protein and was capable of neutralizing RS virus infectivity. Immunization of mice by either the intranasal or the intraperitoneal route with recombinant virus that expressed only the G protein resulted in complete protection of the lower respiratory tract upon subsequent challenge with live RS virus.Entities:
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Year: 1986 PMID: 3773052 PMCID: PMC288932
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103