Literature DB >> 377290

Tropomyosin synthesis accompanies formation of actin filaments in embryonal carcinoma cells induced to differentiate by hexamethylene bisacetamide.

D Paulin, J Perreau, H Jakob, F Jacob, M Yaniv.   

Abstract

Hexamethylene bisacetamide (HMBA) induces in vitro the cytodifferentiation of PCC3/A/1 mouse embryonal carcinoma (EC) cells. In EC cells, actin is associated with surface structures but microfilament bundles are not seen. After 2 days of HMBA treatment, rounded EC cells are converted to flat adhesive ones with a developed cytoskeleton containing actin and tropomyosin. The ratio of actin to total proteins is constant in EC cells and their HMBA derivatives; but a striking difference is observed for one of the newly synthesized proteins (Mr 34,000) identified as tropomyosin. Synthesis of tropomyosin is followed by its association with actin microfilament bundles, as revealed by indirect immunofluorescence microscopy with specific antibodies.

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Year:  1979        PMID： 377290      PMCID： PMC383498          DOI： 10.1073/pnas.76.4.1891

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  Measurements of the molecular size of the simian virus 40 large T antigen.

Authors:  J D Griffin; S Light; D M Livingston
Journal:  J Virol       Date:  1978-07       Impact factor: 5.103

2.  [Effects of hexamethylenebisacetamide on the differentiation of embryonal carcinoma cells].

Authors:  H Jakob; P Dubois; H Eisen; F Jacob
Journal:  C R Acad Hebd Seances Acad Sci D       Date:  1978-01

3.  Hexamethylene bisacetamide induces morphologic changes and increased synthesis of procollagen in cell line from glioblastoma multiforme.

Authors:  A S Rabson; R Stern; T S Tralka; J Costa; J Wilczek
Journal:  Proc Natl Acad Sci U S A       Date:  1977-11       Impact factor: 11.205

4.  Alkaline deoxyribonuclease activity in mouse teratocarcinoma cells: variation of enzyme levels during differentiation.

Authors:  L Soriano; D Paulin
Journal:  Biochem Biophys Res Commun       Date:  1978-07-28       Impact factor: 3.575

5.  The Leeuwenhoek Lecture, 1977. Mouse teratocarcinoma and mouse embryo.

Authors:  F Jacob
Journal:  Proc R Soc Lond B Biol Sci       Date:  1978-05-16

Review 6.  The cell surface antigens of mouse embryonal carcinoma cells.

Authors:  G Gachelin
Journal:  Biochim Biophys Acta       Date:  1978-09-18

7.  Stereo immunofluorescence microscopy: I. Three-dimensional arrangement of microfilaments, microtubules and tonofilaments.

Authors:  M Osborn; T Born; H J Koitsch; K Weber
Journal:  Cell       Date:  1978-07       Impact factor: 41.582

8.  FITC-labelled antibody staining of tropomyosin-containing fibrils in smooth, cardiac and skeletal muscle cells, prefusion myoblasts, fibroblasts, endothelial cells and 3T3 cells in culture.

Authors:  J Chamley-Campbell; G R Campbell; U Gröschel-Stewart; G Burnstock
Journal:  Cell Tissue Res       Date:  1977-09-26       Impact factor: 5.249

9.  Distribution of actin and tubulin in cells and in glycerinated cell models after treatment with cytochalasin B (CB).

Authors:  K Weber; P C Rathke; M Osborn; W W Franke
Journal:  Exp Cell Res       Date:  1976-10-15       Impact factor: 3.905

10.  Cell lines derived from teratocarcinomas.

Authors:  J F Nicolas; P Avner; J Gaillard; J L Guenet; H Jakob; F Jacob
Journal:  Cancer Res       Date:  1976-11       Impact factor: 12.701
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  9 in total

1.  Two Drosophila melanogaster tropomyosin genes: structural and functional aspects.

Authors:  C C Karlik; E A Fyrberg
Journal:  Mol Cell Biol       Date:  1986-06       Impact factor: 4.272

2.  A labile inhibitor blocks endo A gene transcription in murine undifferentiated embryonal carcinoma cells.

Authors:  C Crémisi; P Duprey
Journal:  Nucleic Acids Res       Date:  1987-08-11       Impact factor: 16.971

3.  Tropomyosin is decreased in transformed cells.

Authors:  M Hendricks; H Weintraub
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

Review 4.  Structural and functional properties of the non-muscle tropomyosins.

Authors:  G P Côté
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

5.  Evolution of tropomyosin functional domains: differential splicing and genomic constraints.

Authors:  S Colote; J S Widada; C Ferraz; F Bonhomme; J Marti; J P Liautard
Journal:  J Mol Evol       Date:  1988       Impact factor: 2.395

6.  Catabolites produced by the deacetylation of hexamethylenebisacetamide play a key role in murine erythroleukaemic-cell differentiation.

Authors:  E Meilhoc; M J Moutin; H B Osborne
Journal:  Biochem J       Date:  1986-09-15       Impact factor: 3.857

Review 7.  Regulation and patterns of endogenous and exogenous gene expression during differentiation of embryonal carcinoma cells.

Authors:  S Astigiano; M I Sherman; P Abarzúa
Journal:  Environ Health Perspect       Date:  1989-03       Impact factor: 9.031

8.  Differential localization of tropomyosin isoforms in cultured nonmuscle cells.

Authors:  J J Lin; T E Hegmann; J L Lin
Journal:  J Cell Biol       Date:  1988-08       Impact factor: 10.539

9.  Control by the extracellular environment of differentiation pathways in 1003 embryonal carcinoma cells: study at the level of specific intermediate filaments.

Authors:  M Darmon; M H Buc-Caron; D Paulin; F Jacob
Journal:  EMBO J       Date:  1982       Impact factor: 11.598
  9 in total

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