| Literature DB >> 3771425 |
Abstract
The selective growth of resistant variants, present at low frequencies, varied with different strains of Enterobacteriaceae and different aminoglycosides. This phenomenon was more pronounced during incubation with amikacin than with gentamicin, netilmicin and tobramycin. Selective growth of the resistant variants resulted in an inoculum effect and an increase in MIC with longer incubation. In-vitro evaluation of this phenomenon may be justified when choosing an aminoglycoside for therapy.Entities:
Mesh：
Substances：
Year: 1986 PMID： 3771425 DOI： 10.1093/jac/18.3.317
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790