Literature DB >> 377134

Valproic acid and plasma levels of phenytoin.

J Bruni, B J Wilder, L J Willmore, B Barbour.   

Abstract

Eight patients were treated concurrently with a constant dose of phenytoin and valproic acid for 1 year. During initial therapy with valproic acid, total plasma phenytoin levels decreased. The interaction was transient and was not observed at the end of 1 year. Total plasma phenytoin levels returned to pre-valproic-acid levels in seven patients.

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Year:  1979        PMID： 377134     DOI： 10.1212/wnl.29.6.904

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  4 in total

1.  Interaction between valproate formulation and phenytoin concentrations.

Authors:  Y Suzuki; T Nagai; T Mano; H Arai; R Kodaka; T Matsuoka; Y Itagaki; J Ono; S Okada
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953

2.  Effect of sodium valproate on carbamazepine disposition and psychomotor profile in man.

Authors:  G J Macphee; J R Mitchell; L Wiseman; A R McLellan; B K Park; G T McInnes; M J Brodie
Journal:  Br J Clin Pharmacol       Date:  1988-01       Impact factor: 4.335

Review 3.  Drug interactions with valproic acid.

Authors:  R H Levy; K M Koch
Journal:  Drugs       Date:  1982-12       Impact factor: 9.546

Review 4.  Chromatin Imbalance as the Vertex Between Fetal Valproate Syndrome and Chromatinopathies.

Authors:  Chiara Parodi; Elisabetta Di Fede; Angela Peron; Ilaria Viganò; Paolo Grazioli; Silvia Castiglioni; Richard H Finnell; Cristina Gervasini; Aglaia Vignoli; Valentina Massa
Journal:  Front Cell Dev Biol       Date:  2021-04-20
  4 in total

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