Literature DB >> 3770210

cDNA sequence of human beta-preprotachykinin, the common precursor to substance P and neurokinin A.

A J Harmar, A Armstrong, J C Pascall, K Chapman, R Rosie, A Curtis, J Going, C R Edwards, G Fink.   

Abstract

The nucleotide sequence of cDNA encoding the human substance P precursor, beta-preprotachykinin (beta-PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human beta-PPT polypeptide is 129 amino acids long and contains regions encoding substance P and neurokinin A, each flanked by basic amino acid residues. Residues 72-107 of the human beta-PPT polypeptide encode the sequence of neuropeptide K, an N-terminally extended form of neurokinin A recently isolated from porcine brain.

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Year:  1986        PMID： 3770210     DOI： 10.1016/0014-5793(86)81534-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis.

Authors:  D Singh; D D Joshi; M Hameed; J Qian; P Gascón; P B Maloof; A Mosenthal; P Rameshwar
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-04       Impact factor: 11.205

2.  The expression of neurokinin-1 and preprotachykinin-1 in breast cancer cells depends on the relative degree of invasive and metastatic potential.

Authors:  Tammy A Castro; Marion C Cohen; Pranela Rameshwar
Journal:  Clin Exp Metastasis       Date:  2006-04-27       Impact factor: 5.150

3.  Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P-induced salivation.

Authors:  Y Takeda; J E Krause
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

4.  Expression of striatal preprotachykinin mRNA in symptomatic and asymptomatic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-exposed monkeys is related to parkinsonian motor signs.

Authors:  T V Wade; J S Schneider
Journal:  J Neurosci       Date:  2001-07-01       Impact factor: 6.167

5.  Sera from patients with falciparum malaria induce substance P gene expression in cultured human brain microvascular endothelial cells.

Authors:  C B Chiwakata; G Hort; C J Hemmer; M Dietrich
Journal:  Infect Immun       Date:  1996-12       Impact factor: 3.441

6.  Tachykinins and tachykinin receptors in human uterus.

Authors:  Eva Patak; M Luz Candenas; Jocelyn N Pennefather; Sebastian Ziccone; Alison Lilley; Julio D Martín; Carlos Flores; Antonio G Mantecón; Margot E Story; Francisco M Pinto
Journal:  Br J Pharmacol       Date:  2003-06       Impact factor: 8.739

7.  Post-translational processing of preprotachykinins. Isolation of protachykinin-(1-37)-peptide from human adrenal-medullary phaeochromocytoma tissue.

Authors:  R Kage; L Thim; W Creutzfeldt; J M Conlon
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

8.  The Distribution of Substance P and Kisspeptin in the Mediobasal Hypothalamus of the Male Rhesus Monkey and a Comparison of Intravenous Administration of These Peptides to Release GnRH as Reflected by LH Secretion.

Authors:  Bruna Kalil; Suresh Ramaswamy; Tony M Plant
Journal:  Neuroendocrinology       Date:  2015-11-19       Impact factor: 4.914

9.  Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target.

Authors:  Ernie Chen; Ling-Shiang Chuang; Mamta Giri; Nicole Villaverde; Nai-Yun Hsu; Ksenija Sabic; Sari Joshowitz; Kyle Gettler; Shikha Nayar; Zhi Chai; Isaac L Alter; Colleen C Chasteau; Ujunwa M Korie; Siarhei Dzedzik; Tin Htwe Thin; Aayushee Jain; Arden Moscati; Gerardus Bongers; Richard H Duerr; Mark S Silverberg; Steven R Brant; John D Rioux; Inga Peter; L Philip Schumm; Talin Haritunians; Dermot P McGovern; Yuval Itan; Judy H Cho
Journal:  Gastroenterology       Date:  2021-01-06       Impact factor: 33.883
  9 in total

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