| Literature DB >> 376848 |
D L Klayman, J F Bartosevich, T S Griffin, C J Mason, J P Scovill.
Abstract
Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.Entities:
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Year: 1979 PMID： 376848 DOI： 10.1021/jm00193a020
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446