Literature DB >> 3768032

Identification of two major reduction products of the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide.

K R Laderoute, A M Rauth.   

Abstract

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Year:  1986        PMID： 3768032     DOI： 10.1016/0006-2952(86)90448-x

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


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  8 in total

1.  DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.

Authors:  Venkatraman Junnotula; Anuruddha Rajapakse; Leire Arbillaga; Adela López de Cerain; Beatriz Solano; Raquel Villar; Antonio Monge; Kent S Gates
Journal:  Bioorg Med Chem       Date:  2010-03-19       Impact factor: 3.641

2.  Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.

Authors:  Xiulong Shen; Anuruddha Rajapakse; Fabio Gallazzi; Venkatraman Junnotula; Tarra Fuchs-Knotts; Rainer Glaser; Kent S Gates
Journal:  Chem Res Toxicol       Date:  2013-12-19       Impact factor: 3.739

3.  Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.

Authors:  Venkatraman Junnotula; Ujjal Sarkar; Sarmistha Sinha; Kent S Gates
Journal:  J Am Chem Soc       Date:  2009-01-28       Impact factor: 15.419

4.  SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures.

Authors:  K A Biedermann; J Wang; R P Graham; J M Brown
Journal:  Br J Cancer       Date:  1991-03       Impact factor: 7.640

5.  Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).

Authors:  Kevin M Johnson; Zachary D Parsons; Charles L Barnes; Kent S Gates
Journal:  J Org Chem       Date:  2014-07-25       Impact factor: 4.354

6.  Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

Authors:  Yongchuan Gu; Tony T-A Chang; Jingli Wang; Jagdish K Jaiswal; David Edwards; Noel J Downes; H D Sarath Liyanage; Courtney R H Lynch; Frederik B Pruijn; Anthony J R Hickey; Michael P Hay; William R Wilson; Kevin O Hicks
Journal:  Front Pharmacol       Date:  2017-08-11       Impact factor: 5.810

Review 7.  The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy.

Authors:  Yue Li; Long Zhao; Xiao-Feng Li
Journal:  Front Pharmacol       Date:  2021-04-19       Impact factor: 5.810

Review 8.  Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions.

Authors:  Guyue Cheng; Wei Sa; Chen Cao; Liangliang Guo; Haihong Hao; Zhenli Liu; Xu Wang; Zonghui Yuan
Journal:  Front Pharmacol       Date:  2016-03-21       Impact factor: 5.810
  8 in total

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