A part of codon bias in genes protects protein spatial structures from destabilization by random single point mutations.

Relationships are examined, using a primitive approximation, between the known general codon bias in genes and resistance of protein tertiary structure to destabilization by random single point mutations. A correlation of these two properties is found in the case of the first codon position while the second and third codon positions are evidently used for other purposes. This study suggests a separation of roles of the particular codon positions in the translation of the genetic message.