Literature DB >> 3766951

Tissue porphyrin pattern determination by high-speed high-performance liquid chromatography.

S W Kennedy, D C Wigfield, G A Fox.   

Abstract

A rapid and sensitive method for the determination of porphyrin carboxylic acids in liver, kidney, and spleen by high-speed high-performance liquid chromatography is described. Porphyrins were extracted with recoveries greater than or equal to 98%, concentrated on disposable octadecylsilyl cartridges, and analyzed with a liquid chromatograph equipped with a 3 microns X 3 cm octadecylsilyl column and a fluorescence detector. Separation of di-, tetra-, penta-, hexa-, hepta-, and octacarboxylic acids was achieved within 5 min. The detection limits for uro, copro, and protoporphyrin were 20, 10, and 20 fmol, respectively.

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Year:  1986        PMID： 3766951     DOI： 10.1016/0003-2697(86)90187-9

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  6 in total

1.  Porphyria in a New Zealand White rabbit.

Authors:  S Samman; S H Fussell; C I Rose
Journal:  Can Vet J       Date:  1991-10       Impact factor: 1.008

2.  Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor.

Authors:  A Verma; J S Nye; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

3.  The role of the Ah locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice.

Authors:  M E Hahn; T A Gasiewicz; P Linko; J A Goldstein
Journal:  Biochem J       Date:  1988-08-15       Impact factor: 3.857

4.  Synergistic effect of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat.

Authors:  A P van Birgelen; K M Fase; J van der Kolk; H Poiger; A Brouwer; W Seinen; M van den Berg
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031

5.  Pulsed versus continuous wave excitation mechanisms in photodynamic therapy of differently graded squamous cell carcinomas in tumor-implanted nude mice.

Authors:  P C Rausch; F Rolfs; M R Winkler; A Kottysch; A Schauer; W Steiner
Journal:  Eur Arch Otorhinolaryngol       Date:  1993       Impact factor: 2.503

Review 6.  Toxicological investigations of pollutant-related effects in Great Lakes gulls.

Authors:  D B Peakall; G A Fox
Journal:  Environ Health Perspect       Date:  1987-04       Impact factor: 9.031
  6 in total

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