Literature DB >> 3763057

[125I]LSD labels 5-HT1C recognition sites in pig choroid plexus membranes. Comparison with [3H]mesulergine and [3H]5-HT binding.

D Hoyer, S Srivatsa, A Pazos, G Engel, J M Palacios.   

Abstract

The mammalian choroid plexus is enriched in a newly described serotonin recognition site, the 5-HT1C site. In order to further characterize these sites, the binding characteristics of [125I]LSD, [3H]mesulergine and [3H]serotonin to pig choroid plexus membranes were compared. These ligands labelled with high affinity a similar number of sites. The binding profiles of the sites labelled with these radioligands are indistinguishable as illustrated by highly significant correlation parameters. These sites are very similar to those labelled by N1-methyl-2-[125I]LSD in pig and rat choroid plexus membranes. The data demonstrate that these ligands label 5-HT1C recognition sites in pig and rat choroid plexus membranes.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3763057     DOI： 10.1016/0304-3940(86)90492-1

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  10 in total

Review 1.  PET tracers for serotonin receptors and their applications.

Authors:  J S Dileep Kumar; J John Mann
Journal:  Cent Nerv Syst Agents Med Chem       Date:  2014

Review 2.  A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment.

Authors:  Jose M Palacios; Angel Pazos; Daniel Hoyer
Journal:  Psychopharmacology (Berl)       Date:  2017-03-07       Impact factor: 4.530

3.  Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393.

Authors:  C A Briggs; N J Pollock; D E Frail; C L Paxson; R F Rakowski; C H Kang; J W Kebabian
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

Review 4.  Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens.

Authors:  Adam L Halberstadt; Mark A Geyer
Journal:  Neuropharmacology       Date:  2011-01-20       Impact factor: 5.250

Review 5.  "Selective" serotonin 5-HT2A receptor antagonists.

Authors:  Austen B Casey; Meng Cui; Raymond G Booth; Clinton E Canal
Journal:  Biochem Pharmacol       Date:  2022-04-04       Impact factor: 6.100

6.  Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors.

Authors:  Michael L Granda; Stephen M Carlin; Christian K Moseley; Ramesh Neelamegam; Joseph B Mandeville; Jacob M Hooker
Journal:  ACS Chem Neurosci       Date:  2012-12-07       Impact factor: 4.418

7.  5-HT1C receptor-mediated stimulation of inositol phosphate production in pig choroid plexus. A pharmacological characterization.

Authors:  D Hoyer; C Waeber; P Schoeffter; J M Palacios; A Dravid
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-03       Impact factor: 3.000

8.  Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs.

Authors:  R Verheggen; S Freudenthaler; F Meyer-Dulheuer; A J Kaumann
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

9.  Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine.

Authors:  D G Spencer; T Glaser; J Traber
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

10.  Membrane peptidases in the pig choroid plexus and on other cell surfaces in contact with the cerebrospinal fluid.

Authors:  A Bourne; K Barnes; B A Taylor; A J Turner; A J Kenny
Journal:  Biochem J       Date:  1989-04-01       Impact factor: 3.857
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.