Literature DB >> 3761388

A reinterpretation of tyramine sympathomimetic effect and tachyphylaxis.

M Raiteri, G Levi.   

Abstract

In this commentary, the indirect sympathomimetic effect of tyramine and the phenomenon of tyramine tachyphylaxis are reinterpreted in terms of carrier-mediated exchange processes. Extracellular tyramine would exchange with intraterminal noradrenaline and, upon repeated tyramine administration, with a mixture of noradrenaline and tyramine progressively more enriched in the pharmacologically inactive amine.

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Year:  1986        PMID: 3761388     DOI: 10.1002/jnr.490160211

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN: 0360-4012            Impact factor:   4.164


  1 in total

1.  The mechanism of the 3H-noradrenaline releasing effect of various substrates of uptake1: role of monoamine oxidase and of vesicularly stored 3H-noradrenaline.

Authors:  A Langeloh; U Trendelenburg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-12       Impact factor: 3.000

  1 in total

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