Literature DB >> 3760894

A pharmacodynamic evaluation of midazolam as an antiepileptic compound.

S Jawad, J Oxley, J Wilson, A Richens.   

Abstract

Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration. It is currently used for pre-medication and the induction of anaesthesia. Its antiepileptic properties have been evaluated by studying its effect on interictal spikes on the EEG of six adult epileptic patients. The results indicate that intramuscular midazolam 15 mg is more effective than intramuscular diazepam 10 mg in abolishing interictal spikes and as effective as intravenous diazepam 20 mg five minutes after administration.

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Year:  1986        PMID： 3760894      PMCID： PMC1029011          DOI： 10.1136/jnnp.49.9.1050

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  5 in total

1.  Methods of assessment of antiepileptic drugs.

Authors:  N Milligan; A Richens
Journal:  Br J Clin Pharmacol       Date:  1981-05       Impact factor: 4.335

2.  Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG.

Authors:  N Milligan; S Dhillon; J Oxley; A Richens
Journal:  Epilepsia       Date:  1982-06       Impact factor: 5.864

3.  Acute effects of intravenous phenytoin on the frequency of inter-ictal spikes in man.

Authors:  N Milligan; J Oxley; A Richens
Journal:  Br J Clin Pharmacol       Date:  1983-09       Impact factor: 4.335

4.  Preclinical pharmacology of midazolam.

Authors:  L Pieri
Journal:  Br J Clin Pharmacol       Date:  1983       Impact factor: 4.335

5.  RO 21-3981 for intravenous surgical premedication and induction of anesthesia.

Authors:  J T Conner; R L Katz; R R Pagano; C W Graham
Journal:  Anesth Analg       Date:  1978 Jan-Feb       Impact factor: 5.108
  5 in total
  11 in total

Review 1.  Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs.

Authors:  J W Mandema; M Danhof
Journal:  Clin Pharmacokinet       Date:  1992-09       Impact factor: 6.447

2.  Intramuscular midazolam for treatment of acute seizures or behavioral episodes in patients with brain injuries.

Authors:  B A Wroblewski; A B Joseph
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-04       Impact factor: 10.154

Review 3.  Benzodiazepine sedation in adult ICU patients.

Authors:  R Ritz
Journal:  Intensive Care Med       Date:  1991       Impact factor: 17.440

4.  Midazolam in the treatment of epileptic seizures.

Authors:  S Ghilain; K van Rijckevorsel-Harmant; J Harmant; T H de Barsy
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-05       Impact factor: 10.154

Review 5.  Tonic clonic status epilepticus.

Authors:  S Shorvon
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-02       Impact factor: 10.154

Review 6.  Pharmacokinetic optimization of benzodiazepine therapy for acute seizures. Focus on delivery routes.

Authors:  E Rey; J M Tréluyer; G Pons
Journal:  Clin Pharmacokinet       Date:  1999-06       Impact factor: 6.447

7.  Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study.

Authors:  E Lahat; M Goldman; J Barr; T Bistritzer; M Berkovitch
Journal:  BMJ       Date:  2000-07-08

8.  A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures.

Authors:  Arpita Thakker; Preeti Shanbag
Journal:  J Neurol       Date:  2012-09-16       Impact factor: 4.849

Review 9.  New anticonvulsant drugs. Focus on flunarizine, fosphenytoin, midazolam and stiripentol.

Authors:  M Bebin; T P Bleck
Journal:  Drugs       Date:  1994-08       Impact factor: 9.546

Review 10.  Electroencephalogram-based pharmacodynamic measures: a review.

Authors:  Michael Bewernitz; Hartmut Derendorf
Journal:  Int J Clin Pharmacol Ther       Date:  2012-03       Impact factor: 1.366
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