Urinary glutathione-S-transferase in cisplatin nephrotoxicity in the rat.

Rats given a single toxic dose of cisplatin all developed detectable glutathione-S-transferase activity in their urine between the third and fifth day after injection of cisplatin, simultaneously with the decreased urine osmolality and increased urine volume characteristic of cisplatin nephrotoxicity. Peak urinary glutathione-S-transferase levels occurred at the same time as maximal serum creatinine levels, and there was a significant statistical correlation between these two variables. These findings suggest that urinary glutathione-S-transferase activity is a marker for proximal renal tubular injury from cisplatin.