| Literature DB >> 376000 |
S J Weiss, J Turk, P Needleman.
Abstract
Hydroxyl radical generation was demonstrated during heme-catalyzed decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-mediated inactivation of prostacyclin synthetase seems to be related to the generation of this highly reactive species. A relationship between hydroperoxides and the hydroxyl radical may be important in the modulation of prostacyclin synthesis in diseased states.Entities:
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Year: 1979 PMID： 376000
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113