Literature DB >> 3759338

Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavages of protected peptide resins.

R A Houghten, M K Bray, S T Degraw, C J Kirby.   

Abstract

Methods have recently been presented which greatly increase the ability to synthesize large numbers of peptides. These advances make it essential to be able to cleave large numbers of protected peptide resins. Two different procedures are presented for carrying out cleavage of protected peptide resins. The first procedure enables multiple cleavages to be carried out with many existing HF apparatuses, while the second utilizes a new apparatus design. Using these procedures, at least 50 individual cleavages can be carried out per day.

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Year:  1986        PMID: 3759338     DOI: 10.1111/j.1399-3011.1986.tb01064.x

Source DB:  PubMed          Journal:  Int J Pept Protein Res        ISSN: 0367-8377


  26 in total

1.  Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase.

Authors:  S Roychoudhury; S E Blondelle; S M Collins; M C Davis; H D McKeever; R A Houghten; C N Parker
Journal:  Mol Divers       Date:  1998       Impact factor: 2.943

2.  Analysis of human T-cell epitopes in the 19,000 MW antigen of Mycobacterium tuberculosis: influence of HLA-DR.

Authors:  A Faith; C Moreno; R Lathigra; E Roman; M Fernandez; S Brett; D M Mitchell; J Ivanyi; A D Rees
Journal:  Immunology       Date:  1991-09       Impact factor: 7.397

3.  Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 x 10(12) sequences.

Authors:  C Pinilla; J R Appel; R A Houghten
Journal:  Biochem J       Date:  1994-08-01       Impact factor: 3.857

4.  The effect of lipoylation on CD4 T-cell recognition of the 19,000 MW Mycobacterium tuberculosis antigen.

Authors:  A D Rees; A Faith; E Roman; J Ivanyi; K H Wiesmuller; C Moreno
Journal:  Immunology       Date:  1993-11       Impact factor: 7.397

5.  Mixture-based heterocyclic combinatorial positional scanning libraries: discovery of bicyclic guanidines having potent antifungal activities against Candida albicans and Cryptococcus neoformans.

Authors:  S E Blondelle; E Crooks; J M Ostresh; R A Houghten
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

Review 6.  Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents.

Authors:  S E Blondelle; E Pérez-Payá; R A Houghten
Journal:  Antimicrob Agents Chemother       Date:  1996-05       Impact factor: 5.191

7.  Mapping the detailed specificity of a calcium-dependent monoclonal antibody through the use of soluble positional scanning combinatorial libraries: identification of potent calcium-independent antigens.

Authors:  C Pinilla; J Buencamino; J R Appel; T P Hopp; R A Houghten
Journal:  Mol Divers       Date:  1995-09       Impact factor: 2.943

8.  Two related Epstein-Barr virus membrane proteins are encoded by separate genes.

Authors:  J Sample; D Liebowitz; E Kieff
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

9.  Linear epitopes of the replication-activator protein of Epstein-Barr virus recognised by specific serum IgG in nasopharyngeal carcinoma.

Authors:  H M Cheng; Y T Foong; A J AbuSamah; J Dillner; C K Sam; U Prasad
Journal:  Cancer Immunol Immunother       Date:  1995-04       Impact factor: 6.968

10.  Induced conformational states of amphipathic peptides in aqueous/lipid environments.

Authors:  S E Blondelle; J M Ostresh; R A Houghten; E Pérez-Payá
Journal:  Biophys J       Date:  1995-01       Impact factor: 4.033

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