Literature DB >> 3758302

Effect of lipophilic cations on thiamine transport system in isolated rat hepatocytes.

K Yoshioka, H Nishimura.   

Abstract

The effect of lipophilic cations such as triphenylmethylphosphonium, tetraphenylphosphonium and tetraphenylarsonium in addition to dibenzyldimethylammonium on thiamine transport in isolated rat hepatocytes was studied. Lipophilic cations at the concentration 10 microM almost completely inhibited thiamine uptake. Kinetic studies showed that these compounds were competitive inhibitors with a very high affinity. These results suggest that lipophilic cations in addition to quaternary ammonium compounds also share a common binding site for thiamine in isolated rat hepatocytes.

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Year:  1986        PMID： 3758302     DOI： 10.1007/bf01940715

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Statistical estimations in enzyme kinetics.

Authors:  G N WILKINSON
Journal:  Biochem J       Date:  1961-08       Impact factor: 3.857

2.  Properties of the active thiamine transport system in Ehrlich ascites tumor cells.

Authors:  S Yamamoto; S Koyama; T Kawasaki
Journal:  J Biochem       Date:  1981-03       Impact factor: 3.387

3.  Macrophage membrane potential changes associated with gamma 2b/gamma 1 Fc receptor-ligand binding.

Authors:  J D Young; J C Unkeless; H R Kaback; Z A Cohn
Journal:  Proc Natl Acad Sci U S A       Date:  1983-03       Impact factor: 11.205

4.  Active transport of dimethialium in isolated rat hepatocytes.

Authors:  K Yoshioka; H Nishimura; A Iwashima
Journal:  Biochim Biophys Acta       Date:  1983-07-13

5.  Thiamine transport in the central nervous system.

Authors:  R Spector
Journal:  Am J Physiol       Date:  1976-04

6.  Thiamine transport across the rat intestine. I. Normal characteristics.

Authors:  A M Hoyumpa; H M Middleton; F A Wilson; S Schenker
Journal:  Gastroenterology       Date:  1975-05       Impact factor: 22.682

7.  Transport and metabolism of thiamin in isolated rat hepatocytes.

Authors:  L Lumeng; J W Edmondson; S Schenker; T K Li
Journal:  J Biol Chem       Date:  1979-08-10       Impact factor: 5.157

8.  Effects of thyrotropin on the thyroid cell membrane: hyperpolarization induced by hormone-receptor interaction.

Authors:  E F Grollman; G Lee; F S Ambesi-Impiombato; M F Meldolesi; S M Aloj; H G Coon; H R Kaback; L D Kohn
Journal:  Proc Natl Acad Sci U S A       Date:  1977-06       Impact factor: 11.205

9.  Some properties of the thiamine uptake system in isolated rat hepatocytes.

Authors:  K Yoshioka
Journal:  Biochim Biophys Acta       Date:  1984-11-21

10.  The inhibitory effect of choline and other quaternary ammonium compounds on thiamine transport in isolated rat hepatocytes.

Authors:  K Yoshioka; H Nishimura; M Himukai; A Iwashima
Journal:  Biochim Biophys Acta       Date:  1985-05-28
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