Ibuprofen bio-availability. A comparison of Brufen and Inza.

Ibuprofen in the form of Brufen 200 mg tablets and Inza 200 mg and 400 mg tablets was administered to 18 healthy adult volunteers (9 men and 9 women) in a single-dose (800 mg ibuprofen) open randomized cross-over bio-availability study. Tests revealed increased time required for 50% dissolution to take place for Inza tablets (40-47 minutes) relative to Brufen tablets (7 minutes). Maximum concentration and time to maximum concentration differed significantly (over 20%) between Inza and Brufen, being approximately 30% lower and 67% greater respectively in the case of Inza tablets. Area under plasma concentration time curves were comparable. These data suggest that the Inza tablets tested are not bioequivalent to Brufen 200 mg tablets. Clinical implications are discussed.

RCT Entities:   Population Interventions Outcomes