Testicular toxoplasmosis in two men with the acquired immunodeficiency syndrome (AIDS).

Testicular infection due to Toxoplasma gondii in two young men with the acquired immunodeficiency syndrome manifested as a multifocal necrotizing lesion of the testicular parenchyma. At the periphery of the necrotic area were inflammatory infiltrates consisting mainly of eosinophilic leukocytes. The Toxoplasma organisms were mainly found within the necrotic seminiferous tubules, where they were identified with periodic acid-Schiff or May-Grünwald-Giemsa stains and by electron microscopy. The histologic pattern of this orchitis is characteristic and should be suspected in patients with severe disorders of the immune response.