Literature DB >> 3755142

Monoclonal antibody to macrophages (EMB/11) labels macrophages and microglial cells in human brain.

M M Esiri, J O McGee.   

Abstract

Normal and diseased human central nervous system (CNS) tissues were studied immunohistochemically by a monoclonal antibody to human macrophages (EBM/11), antisera to glial fibrillary acidic protein (anti-GFAP), and alpha-1-antichymotrypsin (alpha 1-ACT). EBM/11 reacted with brain macrophages located mainly around blood vessels in normal brain; it also reacted with resting microglia in normal brain and with numerous reactive microglia and macrophages in brain tumours and inflammatory lesions. Microglia did not react with anti-GFAP or alpha 1-ACT. An EBM/11 positive phenotype, therefore, is shared by microglia and macrophages and suggests that microglial cells form a specialised part of the mononuclear phagocyte system.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3755142      PMCID： PMC499969          DOI： 10.1136/jcp.39.6.615

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  11 in total

1.  Demonstration of cross reaction between anti-macrophage antibodies and mononuclear mesodermal cells.

Authors:  L I Persson; L Rönnbäck
Journal:  Experientia       Date:  1979-03-15

2.  The failure of microglia in normal brain to exhibit mononuclear phagocyte markers.

Authors:  G W Wood; K A Gollahon; S A Tilzer; T Vats; R A Morantz
Journal:  J Neuropathol Exp Neurol       Date:  1979-07       Impact factor: 3.685

3.  Immunohistological analysis of human mononuclear phagocytes and dendritic cells by using monoclonal antibodies.

Authors:  W A Franklin; D Y Mason; K Pulford; B Falini; E Bliss; K C Gatter; H Stein; L C Clarke; J O McGee
Journal:  Lab Invest       Date:  1986-03       Impact factor: 5.662

4.  Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain.

Authors:  V H Perry; D A Hume; S Gordon
Journal:  Neuroscience       Date:  1985-06       Impact factor: 3.590

5.  An immunohistological study of giant-cell tumour of bone: evidence for an osteoclast origin of the giant cells.

Authors:  N A Athanasou; E Bliss; K C Gatter; A Heryet; C G Woods; J O McGee
Journal:  J Pathol       Date:  1985-11       Impact factor: 7.996

6.  Morphological studies on neuroglia. VI. Postnatal development of microglial cells.

Authors:  Y Murabe; Y Sano
Journal:  Cell Tissue Res       Date:  1982       Impact factor: 5.249

7.  Macrophages in experimental and human brain tumors. Part 2: studies of the macrophage content of human brain tumors.

Authors:  R A Morantz; G W Wood; M Foster; M Clark; K Gollahon
Journal:  J Neurosurg       Date:  1979-03       Impact factor: 5.115

8.  Immunofluorescence studies of the monocytes in the injured rat brain.

Authors:  Y Tsuchihashi; T Kitamura; S Fujita
Journal:  Acta Neuropathol       Date:  1981       Impact factor: 17.088

9.  Giant cell myocarditis: evidence for the macrophage origin of the giant cells.

Authors:  J M Theaker; K C Gatter; A Heryet; D J Evans; J O McGee
Journal:  J Clin Pathol       Date:  1985-02       Impact factor: 3.411

10.  Immunohistochemical localization of a macrophage-specific antigen in developing mouse retina: phagocytosis of dying neurons and differentiation of microglial cells to form a regular array in the plexiform layers.

Authors:  D A Hume; V H Perry; S Gordon
Journal:  J Cell Biol       Date:  1983-07       Impact factor: 10.539
View more
  30 in total

Review 1.  Neurovascular unit: a focus on pericytes.

Authors:  Inês Sá-Pereira; Dora Brites; Maria Alexandra Brito
Journal:  Mol Neurobiol       Date:  2012-02-28       Impact factor: 5.590

2.  Labelling of cells of the mononuclear phagocyte system in routinely processed archival biopsy specimens with monoclonal antibody EBM/11.

Authors:  G I Greywoode; S P McCarthy; J O McGee
Journal:  J Clin Pathol       Date:  1990-12       Impact factor: 3.411

3.  Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia.

Authors:  I Grundke-Iqbal; J Fleming; Y C Tung; H Lassmann; K Iqbal; J G Joshi
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

4.  The complex of microglial cells and amyloid star in three-dimensional reconstruction.

Authors:  J Wegiel; H M Wisniewski
Journal:  Acta Neuropathol       Date:  1990       Impact factor: 17.088

5.  Immunophenotypic analysis of infiltrating leukocytes and microglia in an experimental rat glioma.

Authors:  T Morioka; T Baba; K L Black; W J Streit
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

6.  Lectin labelling of amoeboid microglial cells in the brain of postnatal rats.

Authors:  C Kaur; E A Ling; W C Wong
Journal:  J Anat       Date:  1990-12       Impact factor: 2.610

7.  Host defense response to cytomegalovirus in the central nervous system. Predominance of the monocyte.

Authors:  J Booss; P R Dann; B P Griffith; J H Kim
Journal:  Am J Pathol       Date:  1989-01       Impact factor: 4.307

8.  Monoclonal antibody EBM/11: high cellular specificity for human macrophages.

Authors:  P M Kelly; E Bliss; J A Morton; J Burns; J O McGee
Journal:  J Clin Pathol       Date:  1988-05       Impact factor: 3.411

9.  Astrocytes and microglia in human brain share an epitope recognized by a B-lymphocyte-specific monoclonal antibody (LN-1).

Authors:  D W Dickson; L A Mattiace
Journal:  Am J Pathol       Date:  1989-07       Impact factor: 4.307

10.  Macrophage colony-stimulating factor mediates astrocyte-induced microglial ramification in human fetal central nervous system culture.

Authors:  W Liu; C F Brosnan; D W Dickson; S C Lee
Journal:  Am J Pathol       Date:  1994-07       Impact factor: 4.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.