Literature DB >> 3755107

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence.

S Seino, M Welsh, G I Bell, S J Chan, D F Steiner.   

Abstract

A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.

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Year:  1986        PMID： 3755107     DOI： 10.1016/0014-5793(86)81429-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

Review 1.  Proglucagon-derived peptides: nomenclature, biosynthetic relationships and physiological roles.

Authors:  J M Conlon
Journal:  Diabetologia       Date:  1988-08       Impact factor: 10.122

2.  Two dipolar α-helices within hormone-encoding regions of proglucagon are sorting signals to the regulated secretory pathway.

Authors:  Leonardo Guizzetti; Rebecca McGirr; Savita Dhanvantari
Journal:  J Biol Chem       Date:  2014-04-11       Impact factor: 5.157

3.  Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.

Authors:  Y Rouillé; G Westermark; S K Martin; D F Steiner
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

4.  A glucagon-like peptide, structurally related to mammalian oxyntomodulin, from the pancreas of a holocephalan fish, Hydrolagus colliei.

Authors:  J M Conlon; E Dafgård; S Falkmer; L Thim
Journal:  Biochem J       Date:  1987-08-01       Impact factor: 3.857

5.  Colocalization of glucagon-like peptide and glucagon immunoreactivities in pancreatic islets and intestine of salmonids.

Authors:  M Nozaki; K Miyata; Y Oota; A Gorbman; E M Plisetskaya
Journal:  Cell Tissue Res       Date:  1988-08       Impact factor: 5.249

Review 6.  Glucagon-like peptide-1, a new hormone of the entero-insular axis.

Authors:  C Orskov
Journal:  Diabetologia       Date:  1992-08       Impact factor: 10.122

7.  Precipitation of insulinotropin in the presence of protamine: effect of phenol and zinc on the isophane ratio and the insulinotropin concentration in the supernatant.

Authors:  Y Kim; C A Rose
Journal:  Pharm Res       Date:  1995-09       Impact factor: 4.200

8.  Isolation and structural characterization of insulin and glucagon from the holocephalan species Callorhynchus milii (elephantfish).

Authors:  B C Berks; C J Marshall; A Carne; S M Galloway; J F Cutfield
Journal:  Biochem J       Date:  1989-10-01       Impact factor: 3.857

9.  Structure and biological activity of glucagon and glucagon-like peptide from a primitive bony fish, the bowfin (Amia calva).

Authors:  J M Conlon; J H Youson; T P Mommsen
Journal:  Biochem J       Date:  1993-11-01       Impact factor: 3.857
  9 in total

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