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Literature DB >> 3754186

Antibodies to wheat germ agglutinin in coeliac disease.

L M Sollid, J Kolberg, H Scott, J Ek, O Fausa, P Brandtzaeg.

Abstract

Serum IgG and IgA antibodies to wheat germ agglutinin (WGA) were measured by an enzyme-linked immunosorbent assay (ELISA) with N-acetyl-D-glucosamine in all incubation steps to inhibit sugar-specific binding. Patients with coeliac disease (CD) had significantly higher antibody levels to WGA than patients with other intestinal disorders or healthy controls. Similar results were obtained for antibodies to the gluten fraction glyc-gli. The WGA antibodies did apparently not cross-react with gluten antigens, but commercial gluten powder contained traces of WGA or a similar lectin. Our findings support the proposal that WGA may be involved in the pathogenesis of CD.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1986 PMID： 3754186 PMCID： PMC1577348

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

32 in total

1. The binding of a glycopeptide component of wheat gluten to intestinal mucosa of normal and coeliac human subjects.

Authors: A P Douglas
Journal: Clin Chim Acta Date: 1976-12-01 Impact factor: 3.786

2. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals.

Authors: V S Chadwick; S F Phillips; A F Hofmann
Journal: Gastroenterology Date: 1977-08 Impact factor: 22.682

3. Opposing effects of mitogenic and nonmitogenic lectins on lymphocyte activation. Evidence that wheat germ agglutinin produces a negative signal.

Authors: W C Greene; C M Parker; C W Parker
Journal: J Biol Chem Date: 1976-07-10 Impact factor: 5.157

5. The characterization of the repertoire of wheat antigens and peptides involved in the humoral immune responses in patients with gluten sensitivity and Crohn's disease.

Authors: Aristo Vojdani
Journal: ISRN Allergy Date: 2011-10-27

Review 6. The dietary intake of wheat and other cereal grains and their role in inflammation.

Authors: Karin de Punder; Leo Pruimboom
Journal: Nutrients Date: 2013-03-12 Impact factor: 5.717

6 in total

Antibodies to wheat germ agglutinin in coeliac disease.

1. The binding of a glycopeptide component of wheat gluten to intestinal mucosa of normal and coeliac human subjects.

2. Measurements of intestinal permeability using low molecular weight polyethylene glycols (PEG 400). II. Application to normal and abnormal permeability states in man and animals.

3. Opposing effects of mitogenic and nonmitogenic lectins on lymphocyte activation. Evidence that wheat germ agglutinin produces a negative signal.

4. Subunit structure of wheat germ agglutinin.

5. Lectins: cell-agglutinating and sugar-specific proteins.

6. Lectin activity of gluten identified as wheat germ agglutinin.

7. An alternative mechanism for gluten toxicity in coeliac disease.

8. Identification of the dietary lectin, wheat germ agglutinin, in human intestinal contents.

9. Immunofluorescent antibodies against gliadin: a screening test for coeliac disease.

10. Immunoglobulins and dietary protein antibodies in childhood coeliac disease.

1. Serum antibodies to wheat germ agglutinin and gluten in patients with dermatitis herpetiformis.

Review 2. The Impact of Cereal Grain Composition on the Health and Disease Outcomes.

3. Reaction of Lectin-Specific Antibody with Human Tissue: Possible Contributions to Autoimmunity.

Review 4. Is Gluten the Only Culprit for Non-Celiac Gluten/Wheat Sensitivity?

5. The characterization of the repertoire of wheat antigens and peptides involved in the humoral immune responses in patients with gluten sensitivity and Crohn's disease.

Review 6. The dietary intake of wheat and other cereal grains and their role in inflammation.