Literature DB >> 3753968

Isolation and structure of antibiotic U-68,204, a new thiolactone.

L A Dolak, T M Castle, S E Truesdell, O K Sebek.   

Abstract

A new thiolactone-containing antibiotic U-68,204 was found to be produced by a soil actinomycete identified as Streptomyces thiolactonus UC 8478 (NRRL 15,439). The production, isolation, structure determination as well as the physical, spectroscopic and antibacterial properties of this C13H17NO3S compound are here reported. On the basis of these data, the antibiotic was identified as the 10-carboxamide of thiotetromycin.

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Year:  1986        PMID： 3753968     DOI： 10.7164/antibiotics.39.26

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  7 in total

1.  Discovery of FabH/FabF inhibitors from natural products.

Authors:  Katherine Young; Hiranthi Jayasuriya; John G Ondeyka; Kithsiri Herath; Chaowei Zhang; Srinivas Kodali; Andrew Galgoci; Ronald Painter; Vickie Brown-Driver; Robert Yamamoto; Lynn L Silver; Yingcong Zheng; Judith I Ventura; Janet Sigmund; Sookhee Ha; Angela Basilio; Francisca Vicente; José Rubén Tormo; Fernando Pelaez; Phil Youngman; Doris Cully; John F Barrett; Dennis Schmatz; Sheo B Singh; Jun Wang
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Structure of 3-oxoacyl-(acyl-carrier protein) synthase II from Thermus thermophilus HB8.

Authors:  Bagautdin Bagautdinov; Yoko Ukita; Masashi Miyano; Naoki Kunishima
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2008-04-30

3.  SYNTHESIS AND SPECTROSCOPIC DIFFERENTIATION OF 2- AND 4-ALKOXYTHIOTETRONIC ACIDS.

Authors:  Gautham Shenoy; Pilho Kim; Michael Goodwin; Quynh-Anh Nguyen; Clifton E Barry; Cynthia S Dowd
Journal:  Heterocycles       Date:  2004-03-01       Impact factor: 0.831

4.  Novel route to 5-position vinyl derivatives of thiolactomycin: Olefination vs. deformylation.

Authors:  Pilho Kim; Clifton E Barry; Cynthia S Dowd
Journal:  Tetrahedron Lett       Date:  2006-05-15       Impact factor: 2.415

5.  Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation.

Authors:  Xiaoyu Tang; Jie Li; Bradley S Moore
Journal:  Chembiochem       Date:  2017-05-11       Impact factor: 3.164

6.  Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Authors:  Jun Wang; Srinivas Kodali; Sang Ho Lee; Andrew Galgoci; Ronald Painter; Karen Dorso; Fred Racine; Mary Motyl; Lorraine Hernandez; Elizabeth Tinney; Steven L Colletti; Kithsiri Herath; Richard Cummings; Oscar Salazar; Ignacio González; Angela Basilio; Francisca Vicente; Olga Genilloud; Fernando Pelaez; Hiranthi Jayasuriya; Katherine Young; Doris F Cully; Sheo B Singh
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-24       Impact factor: 11.205

7.  A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis.

Authors:  W Tao; M E Yurkovich; S Wen; K E Lebe; M Samborskyy; Y Liu; A Yang; Y Liu; Y Ju; Z Deng; M Tosin; Y Sun; P F Leadlay
Journal:  Chem Sci       Date:  2015-10-08       Impact factor: 9.825
  7 in total

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