Literature DB >> 375393

Extrapituitary action of gonadotropin-releasing hormone: direct inhibition ovarian steroidogenesis.

A J Hsueh, G F Erickson.   

Abstract

Gonadotropin-releasing hormone (GnRH) and its agonistic analogs inhibited the follicle-stimulating hormone (FSH)-induced increase of estrogen and progesterone production in vitro by rat ovarian granulosa cells. Likewise, GnRH analogs inhibited FSH-induced changes in ovarian function in hypophysectomized rats in vivo. These results indicate that GnRH, in addition to its well-known gonadotropin-releasing action in the pituitary, exerts a direct inhibition of ovarian steroidogenesis.

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Year:  1979        PMID： 375393     DOI： 10.1126/science.375393

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  GnRH receptors and GnRH endocrine effects on luteoma cells.

Authors:  A Chamson-Reig; V Lux-Lantos; M Tesone; C Libertun
Journal:  Endocrine       Date:  1997-04       Impact factor: 3.633

Review 2.  Histrelin. A review of its pharmacological properties and therapeutic role in central precocious puberty.

Authors:  L B Barradell; D McTavish
Journal:  Drugs       Date:  1993-04       Impact factor: 9.546

Review 3.  Hormonal aspects of prostatic cancer: a review.

Authors:  J Waxman
Journal:  J R Soc Med       Date:  1985-02       Impact factor: 5.344

4.  Comparative analysis of the effects of gonadotropin-releasing hormone agonist on the proliferative activity, apoptosis, and steroidogenesis in cultured porcine granulosa cells at varying stages of follicular growth.

Authors:  S Takekida; J Deguchi; T Samoto; H Matsuo; T Maruo
Journal:  Endocrine       Date:  2000-02       Impact factor: 3.633

5.  Hormonal regulation of cytodifferentiation and intercellular communication in cultured granulosa cells.

Authors:  A Amsterdam; M Knecht; K J Catt
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

6.  Photoaffinity-labeling and fluorescence-distribution studies of gonadotropin-releasing hormone receptors in ovarian granulosa cells.

Authors:  E Hazum; A Nimrod
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

7.  Anti-tumor and endocrine effects of chronic LHRH agonist treatment (Buserelin) with or without tamoxifen in premenopausal metastatic breast cancer.

Authors:  J G Klijn; F H de Jong; M A Blankenstein; R Docter; J Alexieva-Figusch; J Blonk-van der Wijst; S W Lamberts
Journal:  Breast Cancer Res Treat       Date:  1984       Impact factor: 4.872

8.  Delayed embryo implantation following in vitro fertilization and embryo transfer (IVFET).

Authors:  D Tulchinsky; A Tulchinsky; V Paoletti-Falcone; H Nash; S Pazdziorko; K Brown
Journal:  J Assist Reprod Genet       Date:  1996-08       Impact factor: 3.412

9.  Direct inhibition of testicular function by gonadotropin-releasing hormone: mediation by specific gonadotropin-releasing hormone receptors in interstitial cells.

Authors:  R N Clayton; M Katikineni; V Chan; M L Dufau; K J Catt
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205

10.  Similar luteinizing hormone-releasing hormone binding sites in rat anterior pituitary and ovary.

Authors:  J J Reeves; C Séguin; F A Lefebvre; P A Kelly; F Labrie
Journal:  Proc Natl Acad Sci U S A       Date:  1980-09       Impact factor: 11.205
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