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Literature DB >> 3753614

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues.

J Srinivasappa, J Saegusa, B S Prabhakar, M K Gentry, M J Buchmeier, T J Wiktor, H Koprowski, M B Oldstone, A L Notkins.

Abstract

More than 600 monoclonal antiviral antibodies made against 11 different viruses were screened against 14 different organs from normal uninfected mice. Of these antiviral antibodies, 21, or approximately 3.5%, reacted with specific cells in these organs. Several of these antibodies were of the multiple-organ-reactive type and recognized antigens in more than one organ. It was concluded that the reactivity of monoclonal antiviral antibodies with normal tissues is a common phenomenon.

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Year: 1986 PMID： 3753614 PMCID： PMC252745

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

24 in total

1. Monoclonal immunoglobulin M antibody to Japanese encephalitis virus that can react with a nuclear antigen in mammalian cells.

Authors: E A Gould; A C Chanas; A Buckley; C S Clegg
Journal: Infect Immun Date: 1983-08 Impact factor: 3.441

2. The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.

Authors: J A Tainer; E D Getzoff; H Alexander; R A Houghten; A J Olson; R A Lerner; W A Hendrickson
Journal: Nature Date: 1984 Nov 8-14 Impact factor: 49.962

3. Three monoclonal antibodies against measles virus F protein cross-react with cellular stress proteins.

Authors: H Sheshberadaran; E Norrby
Journal: J Virol Date: 1984-12 Impact factor: 5.103

4. Infection with vaccinia favors the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them cross-reacting with the virus hemagglutinin.

Authors: S Dales; R S Fujinami; M B Oldstone
Journal: J Immunol Date: 1983-09 Impact factor: 5.422

5. Human monoclonal autoantibodies that react with multiple endocrine organs.

Authors: J Satoh; B S Prabhakar; M V Haspel; F Ginsberg-Fellner; A L Notkins
Journal: N Engl J Med Date: 1983-07-28 Impact factor: 91.245

Review 6. Antigenic structure of myoglobin: the complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins.

Authors: M Z Atassi
Journal: Immunochemistry Date: 1975-05

7. Murine monoclonal antibodies reactive with human heart and group A streptococcal membrane antigens.

Authors: M W Cunningham; K Krisher; D C Graves
Journal: Infect Immun Date: 1984-10 Impact factor: 3.441

8. Human multiple organ-reactive monoclonal autoantibody recognizes growth hormone and a 35,000-molecular weight protein.

Authors: J Satoh; K Essani; P R McClintock; A L Notkins
Journal: J Clin Invest Date: 1984-10 Impact factor: 14.808

9. Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products.

Authors: G P Rice; R D Schrier; M B Oldstone
Journal: Proc Natl Acad Sci U S A Date: 1984-10 Impact factor: 11.205

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues.

1. Monoclonal immunoglobulin M antibody to Japanese encephalitis virus that can react with a nuclear antigen in mammalian cells.

2. The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.

3. Three monoclonal antibodies against measles virus F protein cross-react with cellular stress proteins.

4. Infection with vaccinia favors the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them cross-reacting with the virus hemagglutinin.

5. Human monoclonal autoantibodies that react with multiple endocrine organs.

Review 6. Antigenic structure of myoglobin: the complete immunochemical anatomy of a protein and conclusions relating to antigenic structures of proteins.

7. Murine monoclonal antibodies reactive with human heart and group A streptococcal membrane antigens.

8. Human multiple organ-reactive monoclonal autoantibody recognizes growth hormone and a 35,000-molecular weight protein.

9. Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products.

10. Multiple organ-reactive monoclonal autoantibodies.

1. No evidence of persistent mumps virus infection in inflammatory bowel disease.

Review 2. Detection of persistent measles virus infection in Crohn's disease: current status of experimental work.

3. Demonstration of cytomegalovirus nucleic acids in the coronary arteries of transplanted hearts.

Review 4. Infection as a cause of type 1 diabetes?

Review 5. Molecular mimicry as a mechanism for virus-induced autoimmunity.

6. Lyme borreliosis: host responses to Borrelia burgdorferi.

7. Polyspecific human and murine antibodies to diphtheria and tetanus toxoids and phospholipids.

Review 8. Unresolved issues in theories of autoimmune disease using myocarditis as a framework.

9. Characterization of monoclonal islet cell reactive autoantibodies from the diabetic biobreeding (BB/OK) rat.

10. Autoanti-idiotypes exhibit mimicry of myocyte antigens in virus-induced myocarditis.