Literature DB >> 3753580

Comparing the reduction of nitroimidazoles in bacteria and mammalian tissues and relating it to biological activity.

P Goldman, R L Koch, T C Yeung, E J Chrystal, B B Beaulieu, M A McLafferty, G Sudlow.   

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Year:  1986        PMID： 3753580     DOI： 10.1016/0006-2952(86)90553-8

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


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  7 in total

Review 1.  Why metronidazole is active against both bacteria and parasites.

Authors:  J Samuelson
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

2.  Two atypical L-cysteine-regulated NADPH-dependent oxidoreductases involved in redox maintenance, L-cystine and iron reduction, and metronidazole activation in the enteric protozoan Entamoeba histolytica.

Authors:  Ghulam Jeelani; Afzal Husain; Dan Sato; Vahab Ali; Makoto Suematsu; Tomoyoshi Soga; Tomoyoshi Nozaki
Journal:  J Biol Chem       Date:  2010-06-30       Impact factor: 5.157

3.  Susceptibility of an emetine-resistant mutant of Entamoeba histolytica to multiple drugs and to channel blockers.

Authors:  J C Samuelson; A Burke; J M Courval
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

4.  Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases).

Authors:  Dibyarupa Pal; Sulagna Banerjee; Jike Cui; Aaron Schwartz; Sudip K Ghosh; John Samuelson
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191

Review 5.  Individual variation in first-pass metabolism.

Authors:  Y K Tam
Journal:  Clin Pharmacokinet       Date:  1993-10       Impact factor: 6.447

6.  Understanding the broad substrate repertoire of nitroreductase based on its kinetic mechanism.

Authors:  Warintra Pitsawong; John P Hoben; Anne-Frances Miller
Journal:  J Biol Chem       Date:  2014-04-04       Impact factor: 5.157

7.  Genetic variation in metronidazole metabolism and oxidative stress pathways in clinical Giardia lamblia assemblage A and B isolates.

Authors:  Christina S Saghaug; Christian Klotz; Juha P Kallio; Hans-Richard Brattbakk; Tomasz Stokowy; Toni Aebischer; Inari Kursula; Nina Langeland; Kurt Hanevik
Journal:  Infect Drug Resist       Date:  2019-05-10       Impact factor: 4.003
  7 in total

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