Literature DB >> 3753296

The kinetics of penicillin diffusion in serum and middle ear effusions in experimentally induced otitis media.

S K Juhn, J Edlin, T T Jung, G S Giebink.   

Abstract

The kinetics of penicillin diffusion in serum and middle ear effusions (MEE) was studied in experimentally induced serous otitis media (SOM) and purulent otitis media (POM) after systemic injection of procaine-penicillin G. A higher rate of diffusion of penicillin into the middle ear cavity was found in POM than in SOM. The time to reach peak concentrations in MEE was also shorter in POM. Elimination of penicillin from the middle ear cavity was slower in SOM than in POM.

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Year:  1986        PMID： 3753296     DOI： 10.1007/bf00470617

Source DB:  PubMed          Journal:  Arch Otorhinolaryngol        ISSN： 0302-9530


  10 in total

1.  The concentration of penicillin-V in middle ear exudate.

Authors:  K Lundgren; L Ingvarsson; H Rundcrantz
Journal:  Int J Pediatr Otorhinolaryngol       Date:  1979-07       Impact factor: 1.675

2.  Pathogenesis of otitis media.

Authors:  M M Paparella; C S Kim; M V Goycoolea; S Giebink
Journal:  Ann Otol Rhinol Laryngol       Date:  1977 Jul-Aug       Impact factor: 1.547

3.  Clinical pharmacokinetics in preventive antimicrobial therapy.

Authors:  H C Neu
Journal:  South Med J       Date:  1977-10       Impact factor: 0.954

4.  Evaluation of a micromethod for determination of antibiotic concentrations in plasma.

Authors:  B Jalling; A S Malmborg; A Lindman; L O Boréus
Journal:  Eur J Clin Pharmacol       Date:  1972-06       Impact factor: 2.953

5.  Penicillin concentration in middle ear secretion in otitis.

Authors:  E A Lahikainen
Journal:  Acta Otolaryngol       Date:  1970 Nov-Dec       Impact factor: 1.494

6.  Concentration of penicillin V in serum and middle ear exudate during treatment of acute otitis media.

Authors:  L Ingvarsson; C Kamme; K Lundgren
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1980 May-Jun

7.  Studies on middle ear effusions.

Authors:  S K Juhn
Journal:  Laryngoscope       Date:  1982-03       Impact factor: 3.325

8.  Azidocillin and ampicillin concentrations in middle ear effusion.

Authors:  E A Lahikainen; M Vuori; S Virtanen
Journal:  Acta Otolaryngol       Date:  1977 Sep-Oct       Impact factor: 1.494

9.  Pharmacology of oral antibiotics used for treatment of otitis media and tonsillopharyngitis in infants and children.

Authors:  C M Ginsburg; G H McCracken; J D Nelson
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1981 May-Jun

10.  Clinical pharmacology of the antimicrobial agents for infections in the ear, nose and throat.

Authors:  H C Neu
Journal:  Ann Otol Rhinol Laryngol Suppl       Date:  1981 May-Jun
  10 in total

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