Literature DB >> 3752014

Lorazepam in the treatment of refractory neonatal seizures. A pilot study.

A Deshmukh, W Wittert, E Schnitzler, H H Mangurten.   

Abstract

Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam. Immediate cessation of seizure activity occurred in all patients within five minutes. Although seizures recurred in two infants eight hours later, frequency and severity diminished. There were no apparent significant side effects attributed to the medication.

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Year:  1986        PMID: 3752014     DOI: 10.1001/archpedi.1986.02140240088032

Source DB:  PubMed          Journal:  Am J Dis Child        ISSN: 0002-922X


  7 in total

Review 1.  Pharmacotherapy for Seizures in Neonates with Hypoxic Ischemic Encephalopathy.

Authors:  Elissa Yozawitz; Arthur Stacey; Ronit M Pressler
Journal:  Paediatr Drugs       Date:  2017-12       Impact factor: 3.022

Review 2.  A comparative review of the adverse effects of anticonvulsants in children with epilepsy.

Authors:  S J Wallace
Journal:  Drug Saf       Date:  1996-12       Impact factor: 5.606

3.  Neonatal Seizures.

Authors:  Michael J. Painter; John Alvin
Journal:  Curr Treat Options Neurol       Date:  2001-05       Impact factor: 3.598

4.  Midazolam: an effective intravenous agent for seizure control.

Authors:  G M Galvin; G A Jelinek
Journal:  Arch Emerg Med       Date:  1987-09

Review 5.  Pharmacological treatment of neonatal seizures: a systematic review.

Authors:  Laurel A Slaughter; Anup D Patel; Jonathan L Slaughter
Journal:  J Child Neurol       Date:  2013-01-14       Impact factor: 1.987

Review 6.  Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives.

Authors:  Maria D Donovan; Brendan T Griffin; Liudmila Kharoshankaya; John F Cryan; Geraldine B Boylan
Journal:  Drugs       Date:  2016-04       Impact factor: 9.546

7.  Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.

Authors:  Simon N Muchohi; Kenneth Obiero; Charles R J C Newton; Bernhards R Ogutu; Geoffrey Edwards; Gilbert O Kokwaro
Journal:  Br J Clin Pharmacol       Date:  2007-07-17       Impact factor: 4.335

  7 in total

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