Minimal change renal disease associated with thymoma and pancreatic carcinoma.

A case of minimal change renal disease associated with thymoma and pancreatic carcinoma is reported. A clinical manifestation of nephrotic syndrome developed about 5 weeks before the patient's demise and two different primary tumors were revealed only at the time of autopsy. Circumstantial evidences support that minimal change disease was a paraneoplastic process related to thymona rather than either the one related to pancreatic carcinoma or a mere coincidence. Review of the literature disclosed five cases of thymona with associated nephrotic syndrome. Herein, we report another case of such an unusual association and compare the present case with the previously reported.