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Literature DB >> 3749608

Effect of bile on cyclosporine absorption in dogs.

R Venkataramanan, H D Perez, T Schwinghammer, G J Burckart, R J Ptachcinski, D H Van Thiel, T E Starzl.

Abstract

Oral absorption of cyclosporine was studied in dogs with and without bile diversion. Blood and bile cyclosporine concentrations were determined by a high pressure liquid chromatographic method. The absorption of cyclosporine was significantly impaired (p less than 0.05) in dogs with bile diversion. Bile and bile salts appear to be essential for the absorption of cyclosporine.

Entities: Chemical Species

Mesh：

Substances：
Cyclosporins

Year: 1986 PMID： 3749608 PMCID： PMC2956489

Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164

14 in total

1. Biliary Excretion of Cyclosporine in Liver Transplant Patients.

Authors: R Venkataramanan; T E Starzl; S Yang; G J Burckart; R J Ptachcinski; B W Shaw; S Iwatsuki; D H Van Thiel; A Sanghvi; H Seltman
Journal: Transplant Proc Date: 1985-02 Impact factor: 1.066

2. Studies on the intestinal absorption of labelled fat-soluble vitamins (A, D, E, and K) via the thoracic-duct lymph in the absence of bile in man.

Authors: L Forsgren
Journal: Acta Chir Scand Suppl Date: 1969

4. Pancreatic lipase-catalyzed hydrolysis of esters of hydroxymethyl phenytoin dissolved in various metabolizable vehicles, dispersed in micellar systems, and in aqueous suspensions.

Authors: F J Alvarez; V J Stella
Journal: Pharm Res Date: 1989-07 Impact factor: 4.200

4 in total

Effect of bile on cyclosporine absorption in dogs.

1. Biliary Excretion of Cyclosporine in Liver Transplant Patients.

2. Studies on the intestinal absorption of labelled fat-soluble vitamins (A, D, E, and K) via the thoracic-duct lymph in the absence of bile in man.

3. Bile salt enhancement of riboflavin and flavin mononucleotide absorption in man.

4. Physiologic surface-active agents and drug absorption. 8. Effect of bile flow on sulfadiazine absorption in the rat.

5. Cyclosporine monitoring in liver transplant patients.

6. Liquid-chromatographic determination of cyclosporin A in blood and plasma.

Review 7. Clinical pharmacokinetics of cyclosporin.

8. Cyclosporin A for the treatment of graft-versus-host disease in man.

9. Cardiac transplantation with cyclosporin A and prednisone.

10. Bile salts facilitate the absorption of heparin from the intestine.

1. Effect of liver dysfunction on cyclosporine pharmacokinetics.

2. The effect of bile duct ligation and bile diversion on FK506 pharmacokinetics in dogs.

Review 3. Optimal timing and indications for cholecystectomy in cardiac transplant patients.

4. Pancreatic lipase-catalyzed hydrolysis of esters of hydroxymethyl phenytoin dissolved in various metabolizable vehicles, dispersed in micellar systems, and in aqueous suspensions.