Topical hyperbaric oxygenation in the treatment of recalcitrant open wounds. A clinical report.

This clinical report discusses various conventional wound-care treatments, discusses the effectiveness of topical hyperbaric oxygenation (THO) in treating ischemic lower extremity ulcers and preventing amputation of the limb, provides treatment guidelines for improving the quality of wound care for recalcitrant cases, and presents two case studies supporting the efficacy of THO. Although other factors in the treatment have important effects, I attribute the success and improved rate of healing to THO therapy in these two cases. Further studies are needed of the effectiveness of THO therapy in improving circulation in ischemic lower extremity wounds, thus preventing amputation and the loss of independence, mobility, and self-esteem.