| Literature DB >> 3748849 |
S Naruse, A Yasui, S Kishida, M Kadowaki, M Hoshino, T Ozaki, P Robberecht, J Christophe, C Yanaihara, N Yanaihara.
Abstract
The effect of helodermin on vascular physiology was studied in anesthetized dogs using a synthetic replicate of helodermin and helodermin related peptides. Intraarterial infusion of helodermin caused a dose-dependent increase in femoral blood flow. Helodermin was 16 times less potent than VIP and 5 times more potent than PHM (human PHI). The helodermin effect lasted significantly longer; the half-life of the helodermin effect was 6.5 times longer than VIP. Synthetic helodermin (Hd) N-terminal fragment Hd(1-27)NH2 retained substantial activity similar to the full helodermin molecule but the prolonged effect was lost. Hd(7-35) and Hd(22-35) were inactive in this system. Intravenous injection of synthetic helodermin produced prolonged systemic hypotension and tachycardia; and, similar to VIP, it increased the common carotid arterial blood flow while those of the superior mesenteric and femoral arteries were decreased. The results demonstrate the VIP-like vasodilating activity and cardiovascular effects of helodermin in anesthetized dogs.Entities:
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Year: 1986 PMID： 3748849 DOI： 10.1016/0196-9781(86)90192-0
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750