Literature DB >> 3746324

Brain gangliosides in the presenile dementia of Pick.

P E Kamp, W A den Hartog Jager, J Maathuis, P A de Groot, J M de Jong, P A Bolhuis.   

Abstract

Histochemical analysis of frontal and temporal lobes from four patients with Pick presenile dementia indicated intracellular and extracellular deposits of gangliosides. Thin layer chromatography of gangliosides disclosed the presence of an unknown ganglioside, a decrease of N-acetylgalactosamine-GDla and an increase of GTla and/or GD2 in white matter of Pick brain. Chromatography of gray matter and quantitation of the sialic acid content yielded results similar to controls. It is suggested that degradation and removal of gangliosides is incomplete in Pick disease.

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Year:  1986        PMID： 3746324      PMCID： PMC1028948          DOI： 10.1136/jnnp.49.8.881

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  9 in total

1.  High-performance thin-layer chromatography and densitometric determination of brain ganglioside compositions of several species.

Authors:  S Ando; N C Chang; R K Yu
Journal:  Anal Biochem       Date:  1978-09       Impact factor: 3.365

2.  The thiobarbituric acid assay of sialic acids.

Authors:  L WARREN
Journal:  J Biol Chem       Date:  1959-08       Impact factor: 5.157

3.  Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.

Authors:  L SVENNERHOLM
Journal:  Biochim Biophys Acta       Date:  1957-06

4.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

5.  The brain ganglioside pattern in presenile and senile dementia.

Authors:  W Op Den Velde; G J Hooghwinkel
Journal:  J Am Geriatr Soc       Date:  1975-07       Impact factor: 5.562

6.  Pick's disease. A clinical, computed tomographic, and histologic study with golgi impregnation observations.

Authors:  A F Wechsler; M A Verity; S Rosenschein; I Fried; A B Scheibel
Journal:  Arch Neurol       Date:  1982-05

7.  Study of ganglioside patterns with two-dimensional and thin-layer chromatography and radioautography; detection of new fucogangliosides and other minor species in rabbit brain.

Authors:  R W Ledeen; J E Haley; J A Skrivanek
Journal:  Anal Biochem       Date:  1981-03-15       Impact factor: 3.365

8.  Direct thin-layer chromatography of gangliosides of a total lipid extract.

Authors:  S Harth; H Dreyfus; P F Urban; P Mandel
Journal:  Anal Biochem       Date:  1978-06-01       Impact factor: 3.365

9.  Hereditary Pick's disease: second re-examination of the large family and discussion of other hereditary cases, with particular reference to electroencephalography, a computerized tomography.

Authors:  J J Groen; L J Endtz
Journal:  Brain       Date:  1982-09       Impact factor: 13.501
  9 in total

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