Literature DB >> 3745175

Isolation and characterization of a putative endogenous benzodiazepineoid (endozepine) from bovine and human brain.

M Shoyab, L E Gentry, H Marquardt, G J Todaro.   

Abstract

A protein termed endozepine (EP) which inhibits the binding of benzodiazepines to synaptosomal membranes (Ki approximately 5 microM) has been purified to electrophoretic homogeneity from bovine and human brain using acidic ethanol/chloroform extraction, Bio-Sil TSK-250 gel permeation chromatography, and reverse-phase high performance liquid chromatographies. Bovine and human EP are single-chain polypeptides and have molecular weights of approximately 10,000. Both proteins are very hydrophilic and contain an abundance of lysine, glutamic, and aspartic residues. Antisera prepared against bovine EP have been used to develop a sensitive radioimmunoassay for the detection of EP in tissue and body fluids. EP immunoreactivity is widely distributed in mammalian tissues, body fluids, and various cell lines. Substantial variation in the concentrations of EP is observed in different regions of the brain.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3745175

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  27 in total

1.  Diazepam-binding inhibitor: a neuropeptide and/or an acyl-CoA ester binding protein?

Authors:  J Knudsen; M Nielsen
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

Review 2.  Acyl-CoA-binding protein (ACBP) and its relation to fatty acid-binding protein (FABP): an overview.

Authors:  J Knudsen
Journal:  Mol Cell Biochem       Date:  1990 Oct 15-Nov 8       Impact factor: 3.396

3.  Arabidopsis cDNA encoding a membrane-associated protein with an acyl-CoA binding domain.

Authors:  M L Chye
Journal:  Plant Mol Biol       Date:  1998-11       Impact factor: 4.076

4.  Porphyrins are endogenous ligands for the mitochondrial (peripheral-type) benzodiazepine receptor.

Authors:  A Verma; J S Nye; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

Review 5.  Acyl-CoA binding proteins: multiplicity and function.

Authors:  R E Gossett; A A Frolov; J B Roths; W D Behnke; A B Kier; F Schroeder
Journal:  Lipids       Date:  1996-09       Impact factor: 1.880

6.  Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.

Authors:  Fredrick T Harris; S M Jamshedur Rahman; Mohamed Hassanein; Jun Qian; Megan D Hoeksema; Heidi Chen; Rosana Eisenberg; Pierre Chaurand; Richard M Caprioli; Masakazu Shiota; Pierre P Massion
Journal:  Cancer Prev Res (Phila)       Date:  2014-05-12

Review 7.  The role of endozepine in the regulation of steroid synthesis.

Authors:  P F Hall
Journal:  Mol Neurobiol       Date:  1995-02       Impact factor: 5.590

Review 8.  The function of acyl-CoA-binding protein (ACBP)/diazepam binding inhibitor (DBI).

Authors:  J Knudsen; S Mandrup; J T Rasmussen; P H Andreasen; F Poulsen; K Kristiansen
Journal:  Mol Cell Biochem       Date:  1993 Jun 9-23       Impact factor: 3.396

9.  Inhibition of hormone-stimulated steroidogenesis in cultured Leydig tumor cells by a cholesterol-linked phosphorothioate oligodeoxynucleotide antisense to diazepam-binding inhibitor.

Authors:  N Boujrad; J R Hudson; V Papadopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205

10.  Yeast acyl-CoA-binding protein: acyl-CoA-binding affinity and effect on intracellular acyl-CoA pool size.

Authors:  J Knudsen; N J Faergeman; H Skøtt; R Hummel; C Børsting; T M Rose; J S Andersen; P Højrup; P Roepstorff; K Kristiansen
Journal:  Biochem J       Date:  1994-09-01       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.