Literature DB >> 3744569

Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide.

C T Evelo, R P Bos, J G Peters, P T Henderson.   

Abstract

Urine of twenty hospital workers was monitored for the excretion of the cytostatic drug cyclophosphamide using GC-MSD. The drug was found to be present above the detection limit of 0.5 microgram/24 h urine in five cases. A clear relationship between cyclophosphamide handling and the detectability of excretion existed. This method developed can be of use for biological monitoring studies directed toward the finding of exposure hazards.

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Year:  1986        PMID： 3744569     DOI： 10.1007/bf00380766

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN： 0340-0131            Impact factor:   3.015


  7 in total

1.  Quantitative GLC determination of cyclophosphamide and isophosphamide in biological specimens.

Authors:  C Pantarotto; A Bossi; G Belvedere; A Martini; M G Donelli; A Frigerio
Journal:  J Pharm Sci       Date:  1974-10       Impact factor: 3.534

2.  Occupational exposure to cyclophosphamide.

Authors:  M Hirst; S Tse; D G Mills; L Levin; D F White
Journal:  Lancet       Date:  1984-01-28       Impact factor: 79.321

3.  Urinary thioether excretion in nurses handling cytotoxic drugs.

Authors:  O Jagun; M Ryan; H A Waldron
Journal:  Lancet       Date:  1982-08-21       Impact factor: 79.321

4.  Plasma cyclophosphamide assay by selective ion monitoring.

Authors:  C Lartigue-Mattei; J L Chabard; C Touzet; H Bargnoux; J Petit; J A Berger
Journal:  J Chromatogr       Date:  1984-10-12

5.  Some aspects of the gas--liquid chromatographic analysis of cyclophosphamide in plasma.

Authors:  N van den Bosch; D de Vos
Journal:  J Chromatogr       Date:  1980-07-11

6.  Chromosome analyses of nurses handling cytostatic agents.

Authors:  H Waksvik; O Klepp; A Brøgger
Journal:  Cancer Treat Rep       Date:  1981 Jul-Aug

7.  Mutagenicity of urine from nurses handling cytostatic drugs, influence of smoking.

Authors:  R P Bos; A O Leenaars; J L Theuws; P T Henderson
Journal:  Int Arch Occup Environ Health       Date:  1982       Impact factor: 3.015
  7 in total
  11 in total

Review 1.  Drugs hazardous to healthcare workers. Evaluation of methods for monitoring occupational exposure to cytostatic drugs.

Authors:  P J Sessink; R P Bos
Journal:  Drug Saf       Date:  1999-04       Impact factor: 5.606

2.  Effectiveness of cleaning of workplace cytotoxic surface.

Authors:  Laetitia Minh Mai Lê; Pierre Alain Jolivot; Hassane Sadou Yaye; André Rieutord; Agnès Bellanger; Dominique Pradeau; Séverine Barbault-Foucher; Eric Caudron
Journal:  Int Arch Occup Environ Health       Date:  2012-04-12       Impact factor: 3.015

Review 3.  The risks of handling cytotoxic drugs. I. Methods of testing exposure.

Authors:  G P Kaijser; W J Underberg; J H Beijnen
Journal:  Pharm Weekbl Sci       Date:  1990-12-14

4.  Reduction in surface contamination with antineoplastic drugs in 22 hospital pharmacies in the US following implementation of a closed-system drug transfer device.

Authors:  Paul J M Sessink; Thomas H Connor; James A Jorgenson; Timothy G Tyler
Journal:  J Oncol Pharm Pract       Date:  2010-02-15       Impact factor: 1.809

5.  Biological monitoring of cyclophosphamide and ifosfamide in urine of hospital personnel occupationally exposed to cytostatic drugs.

Authors:  A S Ensslin; Y Stoll; A Pethran; A Pfaller; H Römmelt; G Fruhmann
Journal:  Occup Environ Med       Date:  1994-04       Impact factor: 4.402

6.  Detection of contamination with antineoplastic agents in a hospital pharmacy department.

Authors:  P J Sessink; R B Anzion; P H Van den Broek; R P Bos
Journal:  Pharm Weekbl Sci       Date:  1992-02-21

7.  Validation of urinary excretion of cyclophosphamide as a biomarker of exposure by studying its renal clearance at high and low plasma concentrations in cancer patients.

Authors:  Maria Hedmer; Peter Höglund; Eva Cavallin-Ståhl; Maria Albin; Bo A G Jönsson
Journal:  Int Arch Occup Environ Health       Date:  2007-06-20       Impact factor: 3.015

8.  Occupational exposure to cytotoxic drugs in two UK oncology wards.

Authors:  E Ziegler; Howard J Mason; P J Baxter
Journal:  Occup Environ Med       Date:  2002-09       Impact factor: 4.402

9.  Environmental and biological monitoring of antineoplastic drugs in four workplaces in a Swedish hospital.

Authors:  M Hedmer; H Tinnerberg; A Axmon; B A G Jönsson
Journal:  Int Arch Occup Environ Health       Date:  2007-12-08       Impact factor: 3.015

10.  Occupational exposure to antineoplastic agents at several departments in a hospital. Environmental contamination and excretion of cyclophosphamide and ifosfamide in urine of exposed workers.

Authors:  P J Sessink; K A Boer; A P Scheefhals; R B Anzion; R P Bos
Journal:  Int Arch Occup Environ Health       Date:  1992       Impact factor: 3.015
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