| Literature DB >> 3744562 |
J J Chase, W Kubey, M H Dulek, C J Holmes, M G Salit, F C Pearson, E Ribi.
Abstract
The ability of monophosphoryl lipid A (MPLA) to enhance nonspecific host resistance to bacterial infections was studied. Mice were treated with MPLA prior to intraperitoneal challenge with Escherichia coli or Staphylococcus epidermidis. Animals received additional MPLA for 2 days postinfection, and survival rates were determined. Ten micrograms of MPLA per mouse significantly improved the survival of animals infected with either bacterial species. Dose-response studies showed significant MPLA-induced protection at doses of 6 micrograms/kg against E. coli challenge and 60 micrograms/kg against S. epidermidis challenge.Entities:
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Year: 1986 PMID： 3744562 PMCID： PMC260854 DOI： 10.1128/iai.53.3.711-712.1986
Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441