Literature DB >> 3743770

Inhibition by interferon (alpha + beta) of mouse liver regeneration and its reversal by putrescine.

S Nishiguchi, S Otani, I Matsui-Yuasa, S Morisawa, T Monna, T Kuroki, K Kobayashi, S Yamamoto.   

Abstract

Mouse interferon (alpha + beta) given to mice by intraperitoneal injection suppressed both the accumulation of putrescine and stimulation of DNA synthesis in liver caused by partial hepatectomy. The suppression of DNA synthesis was completely reversed by exogenous putrescine. The same results were obtained when core 2',5'-oligoadenylate instead of interferon was given to partially hepatectomized mice. These results suggest that interferon inhibits putrescine formation through elevating the 2',5'-oligoadenylate level and thus inhibits DNA synthesis in the regenerating liver.

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Year:  1986        PMID： 3743770     DOI： 10.1016/0014-5793(86)80866-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Reactivation of viral replication after liver resection in patients infected with hepatitis B virus.

Authors:  S Kubo; S Nishiguchi; H Hamba; K Hirohashi; H Tanaka; T Shuto; H Kinoshita; T Kuroki
Journal:  Ann Surg       Date:  2001-01       Impact factor: 12.969

2.  Effect of interferon-alpha2b administration on rat liver regeneration after partial hepatectomy.

Authors:  S E Theocharis; A P Margeli; S D Skaltsas; A S Skopelitou; M G Mykoniatis; C N Kittas
Journal:  Dig Dis Sci       Date:  1997-09       Impact factor: 3.199

3.  Effect of ethanol on polyamine synthesis during liver regeneration in rats.

Authors:  A M Diehl; M Wells; N D Brown; S S Thorgeirsson; C J Steer
Journal:  J Clin Invest       Date:  1990-02       Impact factor: 14.808

4.  Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2.

Authors:  Ryan W Logan; Angela R Ozburn; Rachel N Arey; Kyle D Ketchesin; Alicia Winquist; Andrew Crain; Brian T D Tobe; Darius Becker-Krail; Matthew B Jarpe; Xiangning Xue; Wei Zong; Zhiguang Huo; Puja K Parekh; Xiyu Zhu; Ethan Fitzgerald; Hui Zhang; Jeffrey Oliver-Smith; Lauren M DePoy; Mariah A Hildebrand; Evan Y Snyder; George C Tseng; Colleen A McClung
Journal:  Mol Psychiatry       Date:  2020-11-24       Impact factor: 15.992

5.  Different physiology of interferon-α/-γ in models of liver regeneration in the rat.

Authors:  Danko S Batusic; Alexander von Bargen; Sabine Blaschke; Jozsef Dudas; Giuliano Ramadori
Journal:  Histochem Cell Biol       Date:  2011-07-21       Impact factor: 4.304

6.  Hepatocyte growth factor and epidermal growth factor activity during later stages of rat liver regeneration upon interferon α-2b influence.

Authors:  Brygida Adamek; Marzena Zalewska-Ziob; Joanna K Strzelczyk; Janusz Kasperczyk; Kinga Wołkowska-Pokrywa; Grażyna Spausta; Edyta Hudziec; Andrzej Wiczkowski; Elżbieta Świętochowska; Michał Kukla; Zofia Ostrowska
Journal:  Clin Exp Hepatol       Date:  2017-01-30
  6 in total

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