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Literature DB >> 3743621

Methotrexate in erythrocytes of patients with psoriasis.

Abstract

Methotrexate (MTX) concentrations in erythrocytes in 32 psoriatics treated weekly with MTX p.o. or i.m. have been studied. When treatment had been constant for at least 5 weeks, there was only small variation in erythrocyte MTX (ery-MTX) in the week between two courses of treatment. The ery-MTX was correlated with the weekly dose of MTX. For patients treated with MTX i.m. r = 0.87, and in patients given divided oral doses r was 0.68. There was no difference in ery-MTX between the two routes of administration. No correlation was observed between ery-MTX and the total MTX dose or the length of treatment. During constant MTX administration small variations in ery-MTX were observed. Small changes in the weekly dose of MTX resulted in marked changes in ery-MTX in 4 of the 5 patients studied.

Entities: Chemical Disease Species

Mesh：

Substances：
Methotrexate

Year: 1986 PMID： 3743621 DOI： 10.1007/bf00607959

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

19 in total

1. Pharmacokinetics of methotrexate in erythrocytes in psoriasis.

Authors: J Hendel; A Nyfors
Journal: Eur J Clin Pharmacol Date: 1984 Impact factor: 2.953

2. Changes in liver histology during methotrexate therapy of psoriasis correlated to the concentration of methotrexate and folate in erythrocytes.

Authors: J Hendel; H Poulsen; B Nyfors; A Nyfors
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1985-04

Review 3. Methotrexate guidelines--revised.

Authors: H H Roenigk; R Auerbach; H I Maibach; G D Weinstein
Journal: J Am Acad Dermatol Date: 1982-02 Impact factor: 11.527

4. Pharmacokinetics of oral methotrexate in children.

Authors: F M Balis; J L Savitch; W A Bleyer
Journal: Cancer Res Date: 1983-05 Impact factor: 12.701

5. Methotrexate and folate content of erythrocytes in patients receiving oral vs intramuscular therapy with methotrexate.

Authors: B A Kamen; J S Holcenberg; K Turo; V M Whitehead
Journal: J Pediatr Date: 1984-01 Impact factor: 4.406

6. Methotrexate pharmacokinetics in age-fractionated erythrocytes.

Authors: H Schrøder
Journal: Cancer Chemother Pharmacol Date: 1986 Impact factor: 3.333

7. Methotrexate-induced malabsorption in children with acute lymphoblastic leukaemia.

Authors: A W Craft; H Kay; D N Lawson; T J McElwain
Journal: Br Med J Date: 1977-12-10

8. Pharmacokinetics of erythrocyte methotrexate in children with acute lymphoblastic leukemia during maintenance treatment.

Authors: H Schrøder; N Clausen; E Ostergaard; T Pressler
Journal: Cancer Chemother Pharmacol Date: 1986 Impact factor: 3.333

2. Methotrexate and its polyglutamate derivatives in erythrocytes during and after weekly low-dose oral methotrexate therapy of children with acute lymphoblastic leukemia.

Authors: H Schrøder; K Fogh
Journal: Cancer Chemother Pharmacol Date: 1988 Impact factor: 3.333

2 in total